Determination of the Optimal Treatment Target in Ulcerative Colitis
This study aims to find the best way to treat ulcerative colitis (UC). UC is a long-term condition that causes inflammation in the large bowel. We know there are different ways to measure how well treatments work, such as looking at symptoms, checking the bowel with a camera, or examining tissue under a microscope. This research compares three different treatment approaches, each with a different goal: one focusing on symptom relief, another on symptom relief and bowel healing, and a third on symptom relief, bowel healing, and microscopic changes. By finding the best target, doctors can improve how they care for people with UC and help develop better medicines for the future.
במבט חטוף
על מה המחקר הזה?
Ulcerative colitis (UC) is a condition where the lining of your large bowel (colon and rectum) becomes inflamed and develops sores, called ulcers. This can cause symptoms like tummy pain, bloody stools, and needing to go to the toilet urgently. Doctors use different ways to check how active your UC is and how well treatments are working. These include asking about your symptoms, using a camera to look inside your bowel, and even examining tiny pieces of tissue under a microscope.
This study wants to figure out the very best goal for treating UC. Is it enough just to get rid of your symptoms? Or should we aim for your bowel to look healthy inside when examined with a camera? Or should we go even further and make sure the tiny cells in your bowel look healthy under a microscope too? By comparing these different goals, the researchers hope to find the most effective approach to help people with UC live healthier lives.
Finding the optimal treatment goal is really important. It will help doctors in the UK and worldwide decide on the best ways to care for their patients with UC. It will also guide scientists and pharmaceutical companies in developing and testing new medications, ensuring they are truly effective at tackling the disease.
נקודות עיקריות
- The study aims to find the *best* treatment goal for Ulcerative Colitis.
- It uses standard UC treatments, not experimental drugs.
- Participants will be divided into three groups, each with a different treatment target.
- Participation involves regular clinic visits, assessments, and close medical monitoring.
- You can withdraw from the study at any time without penalty.
- The findings could improve UC care for many people in the future.
מי עשוי להיות זכאי?
This study is looking for adults aged 18 or older who have been diagnosed with ulcerative colitis. Your UC needs to be moderately or severely active, which means you're currently experiencing symptoms like blood in your stools, and doctors have seen inflammation during a camera examination of your bowel.
You would not be able to join if you've already tried and not responded well to two or more advanced treatments for UC. Also, you must be able to fully participate in all parts of the study, understand what's involved, and give your permission to take part.
Before joining, doctors will also check for certain conditions like tuberculosis and hepatitis B or C. If you're a man or woman who could have children, and you're sexually active, you'll need to agree to use effective contraception during the study and for some time afterwards.
האם מחקר זה יכול להתאים לך?
ענה על השאלות המהירות הללו כדי לבדוק אם אתה עשוי להיות זכאי. זהו מדריך בלבד — צוות המחקר מקבל את ההחלטה הסופית.
- האם אתה בן 18 או יותר?
- Do you have a confirmed diagnosis of Ulcerative Colitis?
- Is your UC currently moderately or severely active?
- Have you *not* had inadequate response to two or more advanced UC treatments?
- Are you able to agree to use contraception if sexually active and potentially able to have children?
מה כרוך בהשתתפות?
If you decide to take part in this study, you will be assigned to one of three groups. Each group will have a different target for your treatment, meaning the doctors will aim to get your UC to a certain level of improvement using standard medications. Your medications will be adjusted over time based on how your body is responding to try and reach your group's specific treatment target.
Throughout the study, you will have regular visits to the clinic where doctors will check your symptoms and perform different assessments. These assessments might include blood tests, stool samples, and occasionally camera examinations (endoscopies) to look inside your bowel. The study is designed to follow your progress and treatment effectiveness over a period of time, although the total duration isn't specified here, it will involve ongoing monitoring and follow-up care until your group's target is either met or a certain period has passed.
סיכונים ותועלות פוטנציאליים
Locations (58)
- St. Joseph Mercy Hospital/Huron Gastroenterology Associatesמיקוד מאומתYpsilanti, United States
- Icahn School of Medicine at Mt Sinai Hospitalמיקוד מאומתניו יורק, ארצות הברית
- New York-Presbyterian/Weill Cornell Medical Centerמיקוד מאומתניו יורק, ארצות הברית
- Digestive Health Partners - Asheville Gastroenterology Associateמיקוד מאומתAsheville, United States
- Atrium Health (Carolinas HealthCare)מיקוד מאומתשארלוט, ארצות הברית
- Gomel Regional Clinical Hospitalמיקוד מאומתHomyel, Belarus
- Vitebsk Regional Clinical Hospitalמיקוד מאומתVitebsk, Belarus
- Imelda Ziekenhuis Bonheidenמיקוד מאומתBonheiden, Belgium
- University Hospital Ghentמיקוד מאומתגנט, בלגיה
- UZ Leuven - University Hospital Gasthuisbergמיקוד מאומתלוון, בלגיה
- אוניברסיטת קלגרימיקוד מאומתקלגרי, קנדה
- GIRI (GI Research Institute)מיקוד מאומתונקובר, קנדה
שאלות נפוצות
What is Ulcerative Colitis (UC)?
UC is a long-term condition causing inflammation and sores in the lining of your large bowel (colon and rectum).
What does 'treatment target' mean?
It's the specific goal doctors aim for when treating your UC, like getting rid of symptoms or healing the bowel lining.
Will I get a new or experimental drug?
No, this study uses standard, approved treatments for UC. It's about finding the best way to use them to achieve different goals.
כמה זמן אהיה במחקר?
The study involves ongoing monitoring and follow-up until your group's treatment target is met or a certain period passes. The exact duration will be explained by the study team.
What if I don't like my assigned treatment group?
You can withdraw from the study at any time, and this will not affect your standard medical care for UC.
כיצד לגלות עוד
תמיד התייעץ עם רופא המשפחה או המומחה שלך לפני שתחליט להשתתף במחקר.
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