A Multi-Arm, Platform Trial For Relapsed Neuroblastoma
This study, called BEACON2, is for children and young people whose neuroblastoma has returned after initial treatment. Neuroblastoma is a type of cancer that starts in nerve cells and is a serious condition for many children. The main goal is to find new and more effective combinations of medicines to help these patients live longer and have a better quality of life. The study will look at how safe these new treatments are, how well they work, and what impact they have on daily life. Researchers will also collect samples to learn more about neuroblastoma and develop better treatments in the future.
במבט חטוף
על מה המחקר הזה?
Neuroblastoma is a type of cancer that usually affects children. While many children are successfully treated, sometimes the cancer is very aggressive, or it comes back after treatment. When this happens, it's called 'relapsed neuroblastoma', and it can be very difficult to treat. Because of this, doctors and scientists are always looking for new and better ways to fight it. That's where studies like BEACON2 come in.
The BEACON2 study aims to improve the chances of survival for children and young people with relapsed neuroblastoma. It does this by testing different combinations of existing medicines to see which ones work best. The study wants to find treatments that are not only effective in getting rid of the cancer but also help children feel as well as possible during treatment. They will closely watch how patients react to the new combinations and whether their quality of life improves.
Along with trying new treatments, the study will also collect samples from patients, like blood or tumour tissue. These samples are really important because they help researchers understand more about neuroblastoma itself. By studying these samples, they hope to discover new clues about why the cancer comes back and how to develop even more targeted treatments in the future to stop it from returning.
נקודות עיקריות
- This study is for children and young people with neuroblastoma that has come back.
- It aims to find better treatment combinations to improve survival and quality of life.
- Different combinations of anti-cancer drugs are being tested.
- Doctors will closely monitor your child's health and treatment response.
- Participation involves regular hospital visits, tests, and long-term follow-up.
- Your child's samples will help researchers learn more about neuroblastoma.
מי עשוי להיות זכאי?
This study is open to children and young people aged 1 year or older who have been diagnosed with neuroblastoma that has come back after previous treatment, and was considered high-risk. To join, doctors must be able to see or measure the cancer using scans or other tests. Unfortunately, if the cancer is only found by looking at bone marrow samples, without other clear signs, then this study might not be suitable.
You also need to be well enough to take part. This means your body, including your blood, kidneys, and liver, needs to be working reasonably well. Doctors will do some tests to check these things. You should also be able to do some normal daily activities, even if you need help getting around. There will be specific medical checks to make sure your body can handle the treatments.
Finally, parents or guardians will need to give their full permission for their child to join the study, and that permission needs to be recorded properly.
האם מחקר זה יכול להתאים לך?
ענה על השאלות המהירות הללו כדי לבדוק אם אתה עשוי להיות זכאי. זהו מדריך בלבד — צוות המחקר מקבל את ההחלטה הסופית.
- Is your child aged 1 year or older?
- Has your child been diagnosed with neuroblastoma that has come back?
- Can the cancer be clearly seen on scans or other tests, not just in bone marrow?
- Is your child generally well enough, with good organ function (checked by doctors)?
- Are you, as a parent or guardian, willing to give informed permission for your child to join?
מה כרוך בהשתתפות?
If you join the BEACON2 study, you will be assigned to one of several treatment groups like choosing Arm A or Arm B, which involve a combination of medicines given over 12 cycles, each lasting three weeks. There are also other groups, like Arm C, which might involve a slightly different combination. These treatments are given as part of your regular hospital visits.
Throughout the study, you'll have regular check-ups, scans, and blood tests to see how you're responding to the treatment and to monitor for any side effects. Researchers will also collect extra samples, like blood or bone marrow, during your routine medical procedures. These extra samples help them understand the disease better. The treatment phase itself lasts for about 9 months (12 cycles x 3 weeks), but visits and check-ups will continue for up to five years after the treatment finishes to see how you are doing in the long term. The study plans to recruit patients for three years.
סיכונים ותועלות פוטנציאליים
Locations (23)
- Sydney Children's Hospital (SCH)מיקוד מאומתSydney, Australia· עדיין לא מגייסים
- St. Anna Children´s Hospitalמיקוד מאומתוינה, אוסטריה· עדיין לא מגייסים
- Cliniques Universitaires Saint-Luc (CUSL)מיקוד מאומתבריסל, בלגיה· עדיין לא מגייסים
- Starship Children's Hospital (SSH)מיקוד מאומתAuckland, New Zealand· עדיין לא מגייסים
- Royal Aberdeen Children's Hospitalמיקוד מאומתAberdeen, United Kingdom· גיוס
- Royal Belfast Hospital for Sick Childrenמיקוד מאומתבלפסט, הממלכה המאוחדת· עדיין לא מגייסים
- Birmingham Children's Hospitalמיקוד מאומתברמינגהאם, הממלכה המאוחדת· גיוס
- Bristol Royal Hospital for Childrenמיקוד מאומתבריסטול, הממלכה המאוחדת· גיוס
- Addenbrookes Hospitalמיקוד מאומתקיימברידג', הממלכה המאוחדת· גיוס
- Children's Hospital for Walesמיקוד מאומתCardiff, United Kingdom· גיוס
- Royal Hospital for Sick Childrenמיקוד מאומתאדינבורו, הממלכה המאוחדת· עדיין לא מגייסים
- Royal Hospital for Childrenמיקוד מאומתגלאזגו, הממלכה המאוחדת· עדיין לא מגייסים
שאלות נפוצות
What is neuroblastoma?
Neuroblastoma is a type of cancer that develops from immature nerve cells found in several areas of the body, most commonly in the adrenal glands.
What does 'relapsed' mean?
Relapsed means the cancer has come back after it was previously treated and seemed to be gone.
איזה סוגי טיפולים נבדקים?
The study tests combinations of medicines like dinutuximab beta, bevacizumab, irinotecan, and temozolomide, which are used to treat cancer.
Will my child automatically receive the new treatment?
If eligible, your child will be assigned to one of the treatment groups, which could be a slightly different combination of medicines being studied.
כמה זמן יימשך המחקר עבור הילד שלי?
The treatment part of the study lasts around 9 months, but your child will be followed up for a total of five years to see how they are doing long-term.
כיצד לגלות עוד
Trial Coordinator
תמיד התייעץ עם רופא המשפחה או המומחה שלך לפני שתחליט להשתתף במחקר.
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