Cytogenetically normal acute myeloid leukemia
עודכן לאחרונה 27 Mar 2023
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Cytogenetically normal acute myeloid leukemia (CN-AML) is one form of a cancer of the blood-forming tissue (bone marrow) called acute myeloid leukemia. In normal bone marrow, early blood cells called hematopoietic stem cells develop into several types of blood cells: white blood cells (leukocytes) that protect the body from infection, red blood cells (erythrocytes) that carry oxygen, and platelets (thrombocytes) that are involved in blood clotting. In acute myeloid leukemia, the bone marrow makes large numbers of abnormal, immature white blood cells called myeloid blasts. Instead of developing into normal white blood cells, the myeloid blasts develop into cancerous leukemia cells. The large number of abnormal cells in the bone marrow interferes with the production of functional white blood cells, red blood cells, and platelets.
תיאור
Cytogenetically normal acute myeloid leukemia (CN-AML) is one form of a cancer of the blood-forming tissue (bone marrow) called acute myeloid leukemia. In normal bone marrow, early blood cells called hematopoietic stem cells develop into several types of blood cells: white blood cells (leukocytes) that protect the body from infection, red blood cells (erythrocytes) that carry oxygen, and platelets (thrombocytes) that are involved in blood clotting. In acute myeloid leukemia, the bone marrow makes large numbers of abnormal, immature white blood cells called myeloid blasts. Instead of developing into normal white blood cells, the myeloid blasts develop into cancerous leukemia cells. The large number of abnormal cells in the bone marrow interferes with the production of functional white blood cells, red blood cells, and platelets.
People with CN-AML have a shortage of all types of mature blood cells: a shortage of white blood cells (leukopenia) leads to increased susceptibility to infections, a low number of red blood cells (anaemia) causes fatigue and weakness, and a reduction in the amount of platelets (thrombocytopenia) can result in easy bruising and abnormal bleeding. Other symptoms of CN-AML may include fever and weight loss.
The age at which CN-AML begins ranges from childhood to late adulthood. CN-AML is said to be an intermediate-risk cancer because the prognosis varies: some affected individuals respond well to normal treatment while others may require stronger treatments. The age at which the condition begins and the prognosis are affected by the specific genetic factors involved in the condition.
Inheritance patterns
The source lists the following possible inheritance patterns: Autosomal dominant; Not inherited. More than one pattern can apply in different cases.
Related genes
Other names
Acute myelogenous leukemia with normal karyotype
CN-AML
NK-AML
Normal karyotype acute myeloid leukemia
Related patient information and medicines
Patient information leaflet
לוקמיה מיאלואידית חריפה
Acute myeloid leukaemia is where the bone marrow makes large numbers of abnormal immatu... These are sometimes called more descriptive names such as acute myelomonocytic leukaemia (this is M4 where the blast cell is one which would normally have developed into a monocyte) ו AML with minimal evidence of myeloid differentiation (this is M0 where.
Patient information leaflet
לוקמיות בילדים
Leukaemia is a cancer of the cells which develop into blood cells. There are different types of leukaemia. The outlook (prognosis) for children with leuk... This leaflet gives a general overview of childhood leukaemias. What is leukaemia. The main types of leukaemia that occur in childhood are: Acute lymphoblastic leukaemia (ALL). Acute myeloid.
Patient information leaflet
לוקמיה
Leukaemia is a cancer of blood-forming cells. There are different types of leukaemia. If you develop leukaemia it is important to know what type it is. Before discussing the different types of leukaemia it may help to know some basics... The main types of leukaemia Acute lymphoblastic leukaemia (ALL). Chronic lymphocytic leukaemia (CLL). Acute.
Patient information leaflet
לוקמיה מיאלואידית כרונית
לוקמיה מיאלואידית כרונית (CML) is sometimes called כרוני myelogenous leukaemia, chronic granulocytic leukaemia, or chronic myelocytic leukaemia. What is chronic myeloid leukaemia. Chronic myeloid leukaemia (CML) is sometimes called ch... Large numbers of these cells are made in the bone marrow and spill into the bloodstream. (In contrast, in.
Patient information leaflet
מיאלופיברוזיס
מיאלופיברוזיס מטופל? a condition affecting the bone marrow and its blood cell production. What is myelofibrosis. Myelofibrosis is a serious bone marrow disorder that disrupts your body's normal production of blood cells. כמה people עם myelofibrosis eventually develop כ type of acute leukaemia called acute myelogenous leukaemia. מיאלופיברוזיס.
Patient information leaflet
לוקמיה לימפובלסטית חריפה
לוקמיה לימפובלסטית חריפה (ALL) is a condition where the bone marrow makes large numbers of abnormal immature lymphocytes. What is acute lymphoblastic leukaemia. Acute lymphoblastic leukaemia (ALL) is a condition where the bone marrow makes large numbers of abnormal immature lymphocytes. The immature cells are called lymphoblasts. The abnormal.
קריאה נוספת והפניות
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