Distal hereditary motor neuropathy, type II
עודכן לאחרונה 4 במרץ 2025
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Distal hereditary motor neuropathy, type II is a progressive disorder that affects nerve cells (neurons) in the brain and spinal cord. This condition specifically affects motor neurons, which are specialized cells that control muscle movement. Damage to motor neurons results in muscle weakness that worsens over time. Distal hereditary motor neuropathy, type II weakness primarily affects movement in the legs.
תיאור
Distal hereditary motor neuropathy, type II is a progressive disorder that affects nerve cells (neurons) in the brain and spinal cord. This condition specifically affects motor neurons, which are specialized cells that control muscle movement. Damage to motor neurons results in muscle weakness that worsens over time. Distal hereditary motor neuropathy, type II weakness primarily affects movement in the legs.
The signs and symptoms of distal hereditary motor neuropathy, type II often begin in adolescence to mid-adulthood. The initial symptoms of the disorder are cramps or weakness in the muscles of the big toe and, later, the entire foot. During the next 5 to 10 years, affected individuals experience a gradual loss of muscle tissue (atrophy) in the lower legs, which can lead to problems with walking (gait disturbance) and high arches (pes cavus). Over time, the lower legs may become paralyzed. The thigh muscles may also undergo muscle atrophy, although this generally occurs later and is less severe than the muscle atrophy in the lower legs.
Some individuals with distal hereditary motor neuropathy, type II can also experience weaken the muscles in the hands and forearms. This weakening is less severe than the weakening in the lower limbs and does not usually lead to paralysis. In rare cases, affected individuals experience hearing loss.
People with distal hereditary motor neuropathy, type II can have exaggerated reflexes (hyperreflexia) or other minor disturbances in the nerves used to detect sensations (sensory neuropathy). Sensory neuropathy is uncommon in people with distal hereditary motor neuropathy, type II and is typically a feature of a disorder calledCharcot-Marie-Tooth disease. These two disorders have overlapping features and can also share a genetic
Inheritance patterns
The source lists the following possible inheritance patterns: Autosomal dominant. More than one pattern can apply in different cases.
Related genes
Other names
Distal hereditary motor neuronopathy, type II
HMN II
HMN2
HMND2
Related patient information and medicines
Patient information leaflet
נוירופתיה פריפרית
Peripheral neuropathy means damage to one or more of your peripheral nerves. The damage means that the messages that travel between your central and peripheral nervous system are disrupted. If motor nerves are damaged, this is known as motor neuropathy. Hereditary diseases Certain diseases that you can inherit from your parents can cause.
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ניוון שרירים
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הפרעות אגירת גליקוגן
הפרעות אגירת גליקוגן are a group of inherited diseases. They result from a problem with one of the proteins (known as enzymes) involved in the conversion of glucose to glycogen, or the breakdown of glycogen back into glucose. They mostly tend to affect your liver and muscles. Most people with a glycogen storage disorder respond well to.
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טיפול בסוף החיים
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מחלת נוירון מוטורי
Motor neurone disease (MND) is a neurological condition causes a progressive weakness ו wasting of many of the muscles in the body. There are various types of motor neurone disease. This leaflet is mainly about amyotrophic lateral sclerosis (ALS), which is the most common type of motor neurone disease. Although there is no cure for motor neurone.
Patient information leaflet
מרפי שרירים
When are muscle relaxants prescribed. Muscle relaxants are used to relieve muscle spasms which may result from some conditions which affect the nervous system, such as: Multiple sclerosis. מחלת נוירון מוטורי. Cerebral palsy. Motor neurone disease Baclofen, tizanidine, dantrolene, ו gabapentin are sometimes used for muscle stiffness or.
קריאה נוספת והפניות
- Distal hereditary motor neuropathy, type II; MedlinePlus, National Library of Medicine.
- Benquey T, Pion E, Cossee M, Krahn M, Stojkovic T, Perrin A, Cerino M, Molon A, Lia AS, Magdelaine C, Francou B, Guiochon-Mantel A, Malinge MC, Leguern E, Levy N, Attarian S, Latour P, Bonello-Palot N. A National French Consensus on Gene List for the Diagnosis of Charcot-Marie-Tooth Disease and Related Disorders Using Next-Generation Sequencing. Genes (Basel). 2022 Feb 9;13(2):318. doi: 10.3390/genes13020318.
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- Tazir M, Nouioua S. Distal hereditary motor neuropathies. Rev Neurol (Paris). 2024 Dec;180(10):1031-1036. doi: 10.1016/j.neurol.2023.09.005. Epub 2024 May 3.
- Tedesco B, Cristofani R, Ferrari V, Cozzi M, Rusmini P, Casarotto E, Chierichetti M, Mina F, Galbiati M, Piccolella M, Crippa V, Poletti A. Insights on Human Small Heat Shock Proteins and Their Alterations in Diseases. Front Mol Biosci. 2022 Feb 25;9:842149. doi: 10.3389/fmolb.2022.842149. eCollection 2022.
- Xie Y, Lin Z, Pakhrin PS, Li X, Wang B, Liu L, Huang S, Zhao H, Cao W, Hu Z, Guo J, Shen L, Tang B, Zhang R. Genetic and Clinical Features in 24 Chinese Distal Hereditary Motor Neuropathy Families. Front Neurol. 2020 Dec 14;11:603003. doi: 10.3389/fneur.2020.603003. eCollection 2020.
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