Intestinal pseudo-obstruction
עודכן לאחרונה 12 Feb 2026
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Intestinal pseudo-obstruction is a condition characterised by impairment of the muscle contractions that move food through the digestive tract. It can occur at any time of life, and its symptoms range from mild to severe. The condition may arise from abnormalities of the gastrointestinal muscles themselves (myogenic) or from problems with the nerves that control the muscle contractions (neurogenic).
תיאור
Intestinal pseudo-obstruction is a condition characterised by impairment of the muscle contractions that move food through the digestive tract. It can occur at any time of life, and its symptoms range from mild to severe. The condition may arise from abnormalities of the gastrointestinal muscles themselves (myogenic) or from problems with the nerves that control the muscle contractions (neurogenic).
Intestinal pseudo-obstruction leads to a buildup of partially digested food in the intestines. This buildup can cause abdominal swelling (distention) and pain, nausea, vomiting, and constipation or diarrhea. Affected individuals experience loss of appetite and impaired ability to absorb nutrients, which may lead to malnutrition. These symptoms resemble those of an intestinal blockage (obstruction), but in intestinal pseudo-obstruction no blockage is found.
Depending on the cause of intestinal pseudo-obstruction, affected individuals can have additional signs and symptoms. Some people with intestinal pseudo-obstruction have bladder dysfunction such as an inability to pass urine. Other, additional features may include decreased muscle tone (hypotonia) or stiffness (spasticity) of the torso and limbs, weakness in the muscles that control eye movement (ophthalmoplegia), intellectual disability, seizures, unusual facial features, or recurrent infections.
When intestinal pseudo-obstruction occurs without additional features, it is called primary or idiopathic intestinal pseudo-obstruction. When the disorder occurs along with other signs and symptoms or as a complication of another health condition, it is called secondary intestinal pseudo-obstruction. The condition can occur once in a while (acute) or steadily (chronic).
Inheritance patterns
The source lists the following possible inheritance patterns: Autosomal recessive; Autosomal dominant; X-linked. More than one pattern can apply in different cases.
Related genes
Other names
Chronic idiopathic intestinal pseudo-obstruction
CIIP
CIPO
Congenital short bowel syndrome
Enteric neuropathy
Familial visceral myopathy
Familial visceral neuropathy
IPO
Paralytic ileus
Pseudo-obstruction of intestine
Pseudointestinal obstruction syndrome
Pseudoobstructive syndrome
Related patient information and medicines
Patient information leaflet
מחלת הירשפרונג
מחלת הירשפרונג is a condition where some of the nerves are missing in a part of the bowel (gut). As a result the bowel muscles can't squeeze properly in that part of the gut. So they can't force the poo through that bit of gut. The poo gets stuck causing a blockage (obstruction). This problem is usually quite apparent early on in life as.
Patient information leaflet
תת-ספיגה במערכת העיכול
Gastrointestinal malabsorption syndrome means a failure to fully absorb digested foods from the gut (bowel) into your body. There are many different causes. Prolonged intestinal malabsorption may cause problems because of a lack of carbohydrates, proteins, fats, minerals and vitamins that are essential to keep you healthy. The treatment will.
Patient information leaflet
התפשלות מעי ותסביב אצל ילדים
התפשלות מעי ו volvulus are two different conditions that cause a blockage of the guts (bowel obstruction). This blockage causes similar symptoms but the cause and treatment are different in the two conditions. התפשלות מעי is a condition where one part of the gut (small intestine/bowel) becomes sucked into the next part of the gut. The.
Patient information leaflet
האם אני יכול לקחת אמפגליפלוזין ותוספי סיבים יחד?
Fournier’s gangrene - empagliflozin Seek immediate medical attention if you experience severe pain, tenderness, redness, or swelling in the genital or anal area, accompanied by fever or a general feeling of being unwell. Intestinal obstruction You must take fibre supplements with a large glass of water (at least 200ml). Taking them without enough.
Patient information leaflet
ג'יארדיה
Giardia intestinalis is a parasite (a living organism that lives on or in another living organism). It can infect the bowels and cause giardiasis. What is giardia. ג'יארדיאזיס מטופל? an infection of the bowels (a גסטרואנטריטיס זיהום). Giardia intestinalis is a protozoan parasite. A protozoa is a microscopic, single-celled organism. Giardiasis is.
Patient information leaflet
שלשול של מטיילים
Do not water down the formula, or make it up with less water than usual. Medication Loperamide is not recommended for children with diarrhoea. There are concerns that it may cause a blockage of the gut (intestinal obstruction) in ילדים with diarrhoea. Most children with traveller's diarrhoea do not need treatment with antibiotics. However, for.
קריאה נוספת והפניות
- Intestinal pseudo-obstruction; MedlinePlus, National Library of Medicine.
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- Lehtonen HJ, Sipponen T, Tojkander S, Karikoski R, Jarvinen H, Laing NG, Lappalainen P, Aaltonen LA, Tuupanen S. Segregation of a missense variant in enteric smooth muscle actin gamma-2 with autosomal dominant familial visceral myopathy. Gastroenterology. 2012 Dec;143(6):1482-1491.e3. doi: 10.1053/j.gastro.2012.08.045. Epub 2012 Sep 6.
- Matera I, Rusmini M, Guo Y, Lerone M, Li J, Zhang J, Di Duca M, Nozza P, Mosconi M, Pini Prato A, Martucciello G, Barabino A, Morandi F, De Giorgio R, Stanghellini V, Ravazzolo R, Devoto M, Hakonarson H, Ceccherini I. Variants of the ACTG2 gene correlate with degree of severity and presence of megacystis in chronic intestinal pseudo-obstruction. Eur J Hum Genet. 2016 Aug;24(8):1211-5. doi: 10.1038/ejhg.2015.275. Epub 2016 Jan 27.
- Milunsky A, Baldwin C, Zhang X, Primack D, Curnow A, Milunsky J. Diagnosis of Chronic Intestinal Pseudo-obstruction and Megacystis by Sequencing the ACTG2 Gene. J Pediatr Gastroenterol Nutr. 2017 Oct;65(4):384-387. doi: 10.1097/MPG.0000000000001608.
- Wangler MF, Gonzaga-Jauregui C, Gambin T, Penney S, Moss T, Chopra A, Probst FJ, Xia F, Yang Y, Werlin S, Eglite I, Kornejeva L, Bacino CA, Baldridge D, Neul J, Lehman EL, Larson A, Beuten J, Muzny DM, Jhangiani S; Baylor-Hopkins Center for Mendelian Genomics; Gibbs RA, Lupski JR, Beaudet A. Heterozygous de novo and inherited mutations in the smooth muscle actin (ACTG2) gene underlie megacystis-microcolon-intestinal hypoperistalsis syndrome. PLoS Genet. 2014 Mar 27;10(3):e1004258. doi: 10.1371/journal.pgen.1004258. eCollection 2014 Mar.
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