activity dependent neuroprotector homeobox
עודכן לאחרונה 18 Aug 2020
עומד בהנחיות העריכה של Patient
- הורדהורד
- שתף
- Language
- דיון
- גרסת שמע
- הוסף למקורות מועדפים בגוגל
ה ADNP gene provides instructions for making a protein that helps control the activity (expression) of other genes through a process called chromatin remodeling. Chromatin is the network of DNA and protein that packages DNA into chromosomes. The structure of chromatin can be changed (remodeled) to alter how tightly DNA is packaged. Chromatin remodeling is one way gene expression is regulated during development; when DNA is tightly packed, gene expression is lower than when DNA is loosely packed. As part of the remodeling process, the ADNP protein attaches to DNA and interacts with groups of proteins called SWI/SNF complexes, which direct changes in the structure of chromatin.
Normal function
ה ADNP gene provides instructions for making a protein that helps control the activity (expression) of other genes through a process called chromatin remodeling. Chromatin is the network of DNA and protein that packages DNA into chromosomes. The structure of chromatin can be changed (remodeled) to alter how tightly DNA is packaged. Chromatin remodeling is one way gene expression is regulated during development; when DNA is tightly packed, gene expression is lower than when DNA is loosely packed. As part of the remodeling process, the ADNP protein attaches to DNA and interacts with groups of proteins called SWI/SNF complexes, which direct changes in the structure of chromatin.
By regulating gene expression, the ADNP protein is involved in many aspects of development. It is particularly important for regulation of genes involved in normal brain development, and it likely controls the activity of genes that direct the development and function of other body systems.
Conditions referring to this gene or chromosome
Other names
activity-dependent neuroprotective protein
activity-dependent neuroprotector
activity-dependent neuroprotector homeobox protein
ADNP homeobox 1
ADNP1
HVDAS
KIAA0784
MRD28
Related patient information and medicines
Patient information leaflet
ריפוי בעיסוק
ריפוי בעיסוק is an essential part of health and social care, and plays a major role in helping people to cope with difficulties of daily living that may occur as a result of physical or mental health difficulties. Occupational therapy (OT) is a health profession, working with individual patients to help them improve their lives at home, at.
Patient information leaflet
הזדקנות
Over time, life expectancy has doubled ב the UK. In 1841, baby boys were not expected to live past the age of 40.2 and girls not past 42.2. For babies born now in the UK, boys can be expected to live for 79.5 years, and girls 83.1 years... Poor health is more likely to make you dependent on other people. Sources of support available for ageing.
Patient information leaflet
אובדן זיכרון ודמנציה
The cause of Alzheimer's disease is not fully understood, but it is thought that abnormal proteins, called plaques and tangles, build up in the brain ו stop it from working properly. Vascular dementia This is the second-most common cause of dementia in older people. Vascular dementia is caused by reduced blood flow to the brain, which damages.
Patient information leaflet
תרגול ופעילות גופנית
Doing regular physical activity can make people feel good about themselves and it can have a number of benefits for health. For example, it reduces the risk of developing heart disease , stroke . Ideally, the aim should be at least 30 minutes of moderate-intensity physical activity on at least five days of the week but even 10 minutes is better.
Patient information leaflet
תסמונת עייפות כרונית
Chronic fatigue syndrome (CFS), sometimes known as myalgic encephalomyelitis (ME) or myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) , is a condition where there is long-term disabling tiredness (fatigue). Most people with also have one or more other symptoms such as muscular pains, joint pains, disturbed sleep patterns, poor.
Patient information leaflet
מחלת הנטינגטון
Physiotherapy You may be referred to a physiotherapist f... Occupational therapy An occupational therapist may be able to help you with any adaptations that you need to make your day-to-day life easier. For example, they can help with adaptations to your home כגון wheelchair access, rails ו changes to your bedroom ו bathroom. טיפול בדיבור.
קריאה נוספת והפניות
- activity dependent neuroprotector homeobox; MedlinePlus, National Library of Medicine.
- Helsmoortel C, Vulto-van Silfhout AT, Coe BP, Vandeweyer G, Rooms L, van den Ende J, Schuurs-Hoeijmakers JH, Marcelis CL, Willemsen MH, Vissers LE, Yntema HG, Bakshi M, Wilson M, Witherspoon KT, Malmgren H, Nordgren A, Anneren G, Fichera M, Bosco P, Romano C, de Vries BB, Kleefstra T, Kooy RF, Eichler EE, Van der Aa N. A SWI/SNF-related autism syndrome caused by de novo mutations in ADNP. Nat Genet. 2014 Apr;46(4):380-4. doi: 10.1038/ng.2899. Epub 2014 Feb 16.
- Malishkevich A, Leyk J, Goldbaum O, Richter-Landsberg C, Gozes I. ADNP/ADNP2 expression in oligodendrocytes: implication for myelin-related neurodevelopment. J Mol Neurosci. 2015 Oct;57(2):304-13. doi: 10.1007/s12031-015-0640-4.
- Mandel S, Rechavi G, Gozes I. Activity-dependent neuroprotective protein (ADNP) differentially interacts with chromatin to regulate genes essential for embryogenesis. Dev Biol. 2007 Mar 15;303(2):814-24. doi: 10.1016/j.ydbio.2006.11.039. Epub 2006 Dec 1.
- Mandel S, Spivak-Pohis I, Gozes I. ADNP differential nucleus/cytoplasm localization in neurons suggests multiple roles in neuronal differentiation and maintenance. J Mol Neurosci. 2008 Jun;35(2):127-41. doi: 10.1007/s12031-007-9013-y. Epub 2008 Feb 20.
- Vandeweyer G, Helsmoortel C, Van Dijck A, Vulto-van Silfhout AT, Coe BP, Bernier R, Gerdts J, Rooms L, van den Ende J, Bakshi M, Wilson M, Nordgren A, Hendon LG, Abdulrahman OA, Romano C, de Vries BB, Kleefstra T, Eichler EE, Van der Aa N, Kooy RF. The transcriptional regulator ADNP links the BAF (SWI/SNF) complexes with autism. Am J Med Genet C Semin Med Genet. 2014 Sep;166C(3):315-26. doi: 10.1002/ajmg.c.31413. Epub 2014 Aug 28.
הצטרפו לשיחה
שתפו את מחשבותיכם או חוויותיכם עם אחרים ב קהילות המטופלים שלנו.
שאלו, שתפו, התחברו.
עיין בדיונים, שאל שאלות ושתף חוויות במאות נושאים בריאותיים.
הירשמו לניוזלטר של פיישנט
המנה השבועית שלך של עצות בריאות ברורות ואמינות - נכתבה כדי לעזור לך להרגיש מעודכן, בטוח ובשליטה.
על ידי הרשמה אתה מקבל את שלנו מדיניות הפרטיות שלנו. באפשרותך לבטל את המנוי בכל עת. לעולם לא נמכור את הנתונים שלך.