glucosamine (N-acetyl)-6-sulfatase
עודכן לאחרונה 18 Aug 2020
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ה GNS gene provides instructions for producing an enzyme called N-acetylglucosamine-6-sulfatase. This enzyme is located in lysosomes, compartments within cells that digest and recycle different types of molecules. N-acetylglucosamine-6-sulfatase is involved in the step-wise breakdown of large molecules called glycosaminoglycans (GAGs). GAGs are composed of sugar molecules that are linked together to form a long string. To break down these large molecules, individual sugars are removed one at a time from one end of the molecule. N-acetylglucosamine-6-sulfatase removes a chemical group known as a sulfate from a subset of GAGs called heparan sulfate when the sugar N-acetylglucosamine-6-sulfate is located at the end.
Normal function
ה GNS gene provides instructions for producing an enzyme called N-acetylglucosamine-6-sulfatase. This enzyme is located in lysosomes, compartments within cells that digest and recycle different types of molecules. N-acetylglucosamine-6-sulfatase is involved in the step-wise breakdown of large molecules called glycosaminoglycans (GAGs). GAGs are composed of sugar molecules that are linked together to form a long string. To break down these large molecules, individual sugars are removed one at a time from one end of the molecule. N-acetylglucosamine-6-sulfatase removes a chemical group known as a sulfate from a subset of GAGs called heparan sulfate when the sugar N-acetylglucosamine-6-sulfate is located at the end.
Conditions referring to this gene or chromosome
Other names
G6S
glucosamine-6-sulfatase
GNS_HUMAN
MGC21274
N-acetylglucosamine-6-sulfatase
N-acetylglucosamine-6-sulfatase precursor
Related patient information and medicines
Patient information leaflet
אוסטיאוארתריטיס
In particular, גלוקוזאמין and chondroitin supplements have become popular in recent years. גלוקוזאמין and chondroitin are chemicals that are p... However, the usefulness of גלוקוזאמין and chondroitin is controversial. This analysed 10 research trials of גלוקוזאמין and chondroitin supplements, involving over 3,800 patients with knee and hip.
Patient information leaflet
האם אני יכול לקחת גלוקוזאמין וסוליפנאצין יחד?
למה זה קורה גלוקוזאמין מטופל? a supplement used for joint health, while solifenacin מטופל? an antimuscarinic medication used for overactive bladder. Diabetes Glucosamine is an amino sugar and may affect your blood glucose levels. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your.
Patient information leaflet
האם אני יכול לקחת גלוקוזאמין ומגנזיום יחד?
למה זה קורה Glucosamine is an amino sugar used by the body to build cartilage, while magnesium is a mineral involved in over 300 enzyme reactions, including muscle and nerve function. Diabetes Glucosamine is an amino sugar and may affect your blood glucose levels. Disclaimer This information is for general educational purposes only and should.
Patient information leaflet
האם אני יכול לקחת גלוקוזאמין ופרע מחורר יחד?
There are no known significant interactions between glucosamine and St John's wort. Why this happens גלוקוזאמין מטופל? primarily used by the body to build cartilage ו does not significantly affect the liver enzymes (Cytochrome P450) that St John's wort is known to influence. S... Diabetes Glucosamine is an amino sugar and may affect your blood.
Patient information leaflet
האם אני יכול לקחת אטורבסטטין וביטוח מפרקים יחד?
Joint Assurance is a supplement that typically contains גלוקוזאמין and chondroitin. However, some people taking statins like atorvastatin report muscle aches, and very rarely, glucosamine might also cause mild muscle or joint discomfort i... Why this happens There are no known pharmacokinetic interactions (how the body processes the drug) or.
Patient information leaflet
האם אני יכול לקחת פורוסמיד וביטוח משותף יחד?
Taking furosemide with Joint Assurance (which contains גלוקוזאמין and chondroitin) may increase the risk of bruising or bleeding if you are also taking blood-thinning medication. ...ne can sometimes affect blood sugar levels,Sulphonamide Allergy If you have a known allergy to sulphonamide antibiotics (such as sulfamethoxazole), you may also be.
קריאה נוספת והפניות
- glucosamine (N-acetyl)-6-sulfatase; MedlinePlus, National Library of Medicine.
- Jansen AC, Cao H, Kaplan P, Silver K, Leonard G, De Meirleir L, Lissens W, Liebaers I, Veilleux M, Andermann F, Hegele RA, Andermann E. Sanfilippo syndrome type D: natural history and identification of 3 novel mutations in the GNS Gene. Arch Neurol. 2007 Nov;64(11):1629-34. doi: 10.1001/archneur.64.11.1629.
- Valstar MJ, Bertoli-Avella AM, Wessels MW, Ruijter GJ, de Graaf B, Olmer R, Elfferich P, Neijs S, Kariminejad R, Suheyl Ezgu F, Tokatli A, Czartoryska B, Bosschaart AN, van den Bos-Terpstra F, Puissant H, Burger F, Omran H, Eckert D, Filocamo M, Simeonov E, Willems PJ, Wevers RA, Niermeijer MF, Halley DJ, Poorthuis BJ, van Diggelen OP. Mucopolysaccharidosis type IIID: 12 new patients and 15 novel mutations. Hum Mutat. 2010 May;31(5):E1348-60. doi: 10.1002/humu.21234.
- Valstar MJ, Ruijter GJ, van Diggelen OP, Poorthuis BJ, Wijburg FA. Sanfilippo syndrome: a mini-review. J Inherit Metab Dis. 2008 Apr;31(2):240-52. doi: 10.1007/s10545-008-0838-5. Epub 2008 Apr 4.
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