potassium voltage-gated channel subfamily Q member 1
עודכן לאחרונה 18 Aug 2020
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ה KCNQ1 gene belongs to a large family of genes that provide instructions for making potassium channels. These channels, which transport positively charged atoms (ions) of potassium out of cells, play key roles in a cell's ability to generate and transmit electrical signals.
Normal function
ה KCNQ1 gene belongs to a large family of genes that provide instructions for making potassium channels. These channels, which transport positively charged atoms (ions) of potassium out of cells, play key roles in a cell's ability to generate and transmit electrical signals.
The specific function of a potassium channel depends on its protein components and its location in the body. Channels made with KCNQ1 proteins are primarily found in the inner ear and in heart (cardiac) muscle. In the inner ear, these channels help maintain the proper ion balance needed for normal hearing. In the heart, the channels are involved in recharging the cardiac muscle after each heartbeat to maintain a regular rhythm. The KCNQ1 protein is also produced in the kidney, lung, stomach, and intestine.
The KCNQ1 protein interacts with proteins in the KCNE family (such as the KCNE1 protein) to form functional potassium channels. Four alpha subunits made from KCNQ1 proteins form the structure of each channel. One beta subunit, made from a KCNE protein, attaches (binds) to the channel and regulates its activity.
Conditions referring to this gene or chromosome
Other names
ATFB1
IKs producing slow voltage-gated potassium channel alpha subunit KvLQT1
JLNS1
KCNA8
KCNA9
KCNQ1_HUMAN
KQT-like 1
Kv1.9
Kv7.1
KVLQT1
LQT1
potassium channel, voltage gated KQT-like subfamily Q, member 1
potassium voltage-gated channel, KQT-like subfamily, member 1
Related patient information and medicines
Patient information leaflet
אנגינה
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האם אני יכול לקחת ביסופרולול ורמיפריל יחד?
Bisoprolol is a beta-blocker that slows the heart rate, while ramipril is an ACE inhibitor that relaxes blood vessels. Because they both target the cardiovascular system, their effects add together (an ad... It is best to keep your alcohol intake within recommended limits and see how the medicine affects you before drinking. Salt substitutes.
Patient information leaflet
האם אני יכול לקחת אטנולול ורמיפריל יחד?
Ou... Simply search for your medicines to see potential interactions and what to do about them. הבהרה This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions.
Patient information leaflet
פגיעה חריפה בכליות
פגיעה חריפה בכליות can be a confusing name as it suggests an accident or injury to that part of your body, eg from a fall or trauma. However, acute kidney injury is actually a condition where your kidneys suddenly stop working properly. If you have acute kidney injury (AKI) your kidneys suddenly stop working as well as they should. This means the.
Patient information leaflet
האם אני יכול לקחת קו-אמוקסיקלב ורמיפריל יחד?
לוקח co-amoxiclav and ramipril together can occasionally increase the risk of a rare but serious allergic reaction called angioedema (swelling under the skin). It may also increase the risk of high potassium levels in the blood or affect your kidney function, especially if you are already unwell with an infection. Our Medicines Interaction.
Patient information leaflet
חיסון 6-ב-1
ה חיסון 6-ב-1 is part of routine childhood immunisations and protects babies against six different serious illnesses. Three doses are given. Further boosters without all six components are given at other times later in childhood and in adult life. The 6-in-1 vaccine used to be given as the 3-in-1 vaccine DTaP along with the polio vaccine.
קריאה נוספת והפניות
- potassium voltage-gated channel subfamily Q member 1; MedlinePlus, National Library of Medicine.
- Arnestad M, Crotti L, Rognum TO, Insolia R, Pedrazzini M, Ferrandi C, Vege A, Wang DW, Rhodes TE, George AL Jr, Schwartz PJ. Prevalence of long-QT syndrome gene variants in sudden infant death syndrome. Circulation. 2007 Jan 23;115(3):361-7. doi: 10.1161/CIRCULATIONAHA.106.658021. Epub 2007 Jan 8.
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- Ellinor PT, Moore RK, Patton KK, Ruskin JN, Pollak MR, Macrae CA. Mutations in the long QT gene, KCNQ1, are an uncommon cause of atrial fibrillation. Heart. 2004 Dec;90(12):1487-8. doi: 10.1136/hrt.2003.027227. No abstract available.
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- Groffen AJ, Bikker H, Christiaans I. Long QT Syndrome Overview. 2003 Feb 20 [updated 2024 Mar 21]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK1129/
- Herbert E, Trusz-Gluza M, Moric E, Smilowska-Dzielicka E, Mazurek U, Wilczok T. KCNQ1 gene mutations and the respective genotype-phenotype correlations in the long QT syndrome. Med Sci Monit. 2002 Oct;8(10):RA240-8.
- Hong K, Piper DR, Diaz-Valdecantos A, Brugada J, Oliva A, Burashnikov E, Santos-de-Soto J, Grueso-Montero J, Diaz-Enfante E, Brugada P, Sachse F, Sanguinetti MC, Brugada R. De novo KCNQ1 mutation responsible for atrial fibrillation and short QT syndrome in utero. Cardiovasc Res. 2005 Dec 1;68(3):433-40. doi: 10.1016/j.cardiores.2005.06.023. Epub 2005 Aug 18.
- Huang L, Bitner-Glindzicz M, Tranebjaerg L, Tinker A. A spectrum of functional effects for disease causing mutations in the Jervell and Lange-Nielsen syndrome. Cardiovasc Res. 2001 Sep;51(4):670-80. doi: 10.1016/s0008-6363(01)00350-9.
- Ioakeimidis NS, Papamitsou T, Meditskou S, Iakovidou-Kritsi Z. Sudden infant death syndrome due to long QT syndrome: a brief review of the genetic substrate and prevalence. J Biol Res (Thessalon). 2017 Mar 14;24:6. doi: 10.1186/s40709-017-0063-1. eCollection 2017 Dec.
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- Melman YF, Um SY, Krumerman A, Kagan A, McDonald TV. KCNE1 binds to the KCNQ1 pore to regulate potassium channel activity. Neuron. 2004 Jun 24;42(6):927-37. doi: 10.1016/j.neuron.2004.06.001.
- Park KH, Piron J, Dahimene S, Merot J, Baro I, Escande D, Loussouarn G. Impaired KCNQ1-KCNE1 and phosphatidylinositol-4,5-bisphosphate interaction underlies the long QT syndrome. Circ Res. 2005 Apr 15;96(7):730-9. doi: 10.1161/01.RES.0000161451.04649.a8. Epub 2005 Mar 3.
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- Tristani-Firouzi M, Sanguinetti MC. Structural determinants and biophysical properties of HERG and KCNQ1 channel gating. J Mol Cell Cardiol. 2003 Jan;35(1):27-35. doi: 10.1016/s0022-2828(02)00286-9.
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