POU class 3 homeobox 4
עודכן לאחרונה 18 Aug 2020
עומד בהנחיות העריכה של Patient
- הורדהורד
- שתף
- Language
- דיון
- גרסת שמע
- הוסף למקורות מועדפים בגוגל
ה POU3F4 gene provides instructions for making a protein that helps regulate the activity of other genes. Based on this role, the protein is called a transcription factor. The POU3F4 gene is part of a larger family of transcription factor genes called POU domain genes. These genes play a role in determining cell types in the brain and spinal cord (the central nervous system) during early development. The proteins produced from genes in the POU domain family each include two regions, called the POU-specific domain and POU homeodomain, that bind to the DNA of other genes.
Normal function
ה POU3F4 gene provides instructions for making a protein that helps regulate the activity of other genes. Based on this role, the protein is called a transcription factor. The POU3F4 gene is part of a larger family of transcription factor genes called POU domain genes. These genes play a role in determining cell types in the brain and spinal cord (the central nervous system) during early development. The proteins produced from genes in the POU domain family each include two regions, called the POU-specific domain and POU homeodomain, that bind to the DNA of other genes.
The POU3F4 protein is likely to be involved in the development of the middle and inner ear, and it is also active in certain regions of the brain before birth. Researchers are working to determine which genes are regulated by this protein.
Conditions referring to this gene or chromosome
Other names
BRAIN-4
brain-specific homeobox/POU domain protein 4
Brn-4
BRN4
DFN3
DFNX2
OTF9
PO34_HUMAN
Related patient information and medicines
Patient information leaflet
פיברומיאלגיה
Sleeping tablets These are not often used, as they do not help with fibromyalgia, and can be addictive. See the separate leaflet called Insomnia (Poor sleep) for tips on getting a good night's sleep. Muscle relaxants One study examine the effects of a medicine called cyclobenzaprine , which is a muscle relaxant. In 2021, the National Institute for.
Patient information leaflet
פקקת ורידים עמוקים
Raised means that your foot is higher than your hip so gravity helps with blood flow returnin... The easiest way to raise your leg is to recline on a sofa with your leg up on a cushion. Sitting on the sofa or in a chair, with your רגליים on a footstool או pouffe, is not keeping your feet up - the feet are well below your hips in this position. Raise.
Patient information leaflet
כיבים ורידיים ברגליים
Venous leg ulcers are common in older people. The most important part of treatment is for compression bandages to be applied correctly by a nurse. The rest of this leaflet deals only with venous leg ulcers. What causes venous leg ... There are different strengths (classes) of compression stockings - class 1, 2 and 3. The higher the class (class 3).
Patient information leaflet
אי ספיקת לב
It is called acute heart failure if it has made you unwell quite suddenly. However, ordinary physical activit... Class 3 (moderate) - although comfortable at rest, slight physical activity כגון dressing yourself causes breathlessness, fatigue, or palpitations. Class 4 (severe) - you are unable to carry out any physical activity without.
Patient information leaflet
סמים לשימוש פנאי
Unwanted sexual intercourse is more likely under the influence of drugs, which may lead to sexually transmitted infections or unwanted pregnancy. How many people use recreational drugs. The government obtains reports on recreational drug use in the UK every year. These are published regularly. The latest statistics at the time of writing this.
Patient information leaflet
מחשבון BMI
BMI (body mass index) is a measure for adults to check what category their height and weight puts them in - underweight, healthy, or overweight. If you’re BMI is in the obese range, you should see your GP and talk about a plan to lower your BMI in a... Severely Obese – Class 3 A BMI of 40 or above means you’re in the range of severe class 3.
קריאה נוספת והפניות
- POU class 3 homeobox 4; MedlinePlus, National Library of Medicine.
- Bademci G, Lasisi A, Yariz KO, Montenegro P, Menendez I, Vinueza R, Paredes R, Moreta G, Subasioglu A, Blanton S, Fitoz S, Incesulu A, Sennaroglu L, Tekin M. Novel domain-specific POU3F4 mutations are associated with X-linked deafness: examples from different populations. BMC Med Genet. 2015 Feb 25;16:9. doi: 10.1186/s12881-015-0149-2.
- Bitner-Glindzicz M, Turnpenny P, Hoglund P, Kaariainen H, Sankila EM, van der Maarel SM, de Kok YJ, Ropers HH, Cremers FP, Pembrey M, et al. Further mutations in Brain 4 (POU3F4) clarify the phenotype in the X-linked deafness, DFN3. Hum Mol Genet. 1995 Aug;4(8):1467-9. doi: 10.1093/hmg/4.8.1467. No abstract available.
- Dang J, Bian P, Chen C, Chen C, Shan W, Cai L, Li Y, Tan H, Xu B, Guan M, Guo Y. Impact of POU3F4 mutation on cochlear development and auditory function. Cell Commun Signal. 2025 Mar 5;23(1):121. doi: 10.1186/s12964-025-02133-y.
- de Kok YJ, van der Maarel SM, Bitner-Glindzicz M, Huber I, Monaco AP, Malcolm S, Pembrey ME, Ropers HH, Cremers FP. Association between X-linked mixed deafness and mutations in the POU domain gene POU3F4. Science. 1995 Feb 3;267(5198):685-8. doi: 10.1126/science.7839145.
- Lee HK, Song MH, Kang M, Lee JT, Kong KA, Choi SJ, Lee KY, Venselaar H, Vriend G, Lee WS, Park HJ, Kwon TK, Bok J, Kim UK. Clinical and molecular characterizations of novel POU3F4 mutations reveal that DFN3 is due to null function of POU3F4 protein. Physiol Genomics. 2009 Nov 6;39(3):195-201. doi: 10.1152/physiolgenomics.00100.2009. Epub 2009 Aug 11.
- Marlin S, Moizard MP, David A, Chaissang N, Raynaud M, Jonard L, Feldmann D, Loundon N, Denoyelle F, Toutain A. Phenotype and genotype in females with POU3F4 mutations. Clin Genet. 2009 Dec;76(6):558-63. doi: 10.1111/j.1399-0004.2009.01215.x.
- Parzefall T, Shivatzki S, Lenz DR, Rathkolb B, Ushakov K, Karfunkel D, Shapira Y, Wolf M, Mohr M, Wolf E, Sabrautzki S, de Angelis MH, Frydman M, Brownstein Z, Avraham KB. Cytoplasmic mislocalization of POU3F4 due to novel mutations leads to deafness in humans and mice. Hum Mutat. 2013 Aug;34(8):1102-10. doi: 10.1002/humu.22339. Epub 2013 May 8.
- Prat Matifoll JA, Wilson M, Goetti R, Birman C, Bennett B, Peadon E, Prats-Uribe A, Prelog K. A Case Series of X-Linked Deafness-2 with Sensorineural Hearing Loss, Stapes Fixation, and Perilymphatic Gusher: MR Imaging and Clinical Features of Hypothalamic Malformations. AJNR Am J Neuroradiol. 2020 Jun;41(6):1087-1093. doi: 10.3174/ajnr.A6541. Epub 2020 May 14.
- Song MH, Lee KY, Choi JY, Bok J, Kim UK. Nonsyndromic X-linked hearing loss. Front Biosci (Elite Ed). 2012 Jan 1;4(3):924-33. doi: 10.2741/E430.
- Su Y, Gao X, Huang SS, Mao JN, Huang BQ, Zhao JD, Kang DY, Zhang X, Dai P. Clinical and molecular characterization of POU3F4 mutations in multiple DFNX2 Chinese families. BMC Med Genet. 2018 Sep 4;19(1):157. doi: 10.1186/s12881-018-0630-9.
הצטרפו לשיחה
שתפו את מחשבותיכם או חוויותיכם עם אחרים ב קהילות המטופלים שלנו.
שאלו, שתפו, התחברו.
עיין בדיונים, שאל שאלות ושתף חוויות במאות נושאים בריאותיים.
הירשמו לניוזלטר של פיישנט
המנה השבועית שלך של עצות בריאות ברורות ואמינות - נכתבה כדי לעזור לך להרגיש מעודכן, בטוח ובשליטה.
על ידי הרשמה אתה מקבל את שלנו מדיניות הפרטיות שלנו. באפשרותך לבטל את המנוי בכל עת. לעולם לא נמכור את הנתונים שלך.