purine rich element binding protein A
עודכן לאחרונה 18 Aug 2020
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ה PURA gene provides instructions for making a protein called Pur-alpha (Purα), which is able to attach (bind) to DNA and RNA (a molecular cousin of DNA). This protein has multiple roles in cells, including controlling the activity of genes (gene transcription) and aiding in the copying (replication) of DNA.
Normal function
ה PURA gene provides instructions for making a protein called Pur-alpha (Purα), which is able to attach (bind) to DNA and RNA (a molecular cousin of DNA). This protein has multiple roles in cells, including controlling the activity of genes (gene transcription) and aiding in the copying (replication) of DNA.
The Purα protein is important for normal brain development. The protein helps direct the growth and division of nerve cells (neurons). It may also be involved in the formation or maturation of myelin, the protective substance that covers nerves and promotes the efficient transmission of nerve impulses.
Conditions referring to this gene or chromosome
Other names
MRD31
PUR-ALPHA
PUR1
PURALPHA
purine-rich single-stranded DNA-binding protein alpha
transcriptional activator protein Pur-alpha
Related patient information and medicines
Patient information leaflet
האם אני יכול לקחת אלופורינול ונורטריפטילין יחד?
Water / Fluids It is important to drink plenty of fluids (at least 2 to... This helps to prevent the formation of kidney stones and ensures the medicine works correctly to flush uric acid from your system. Purine-rich foods (e.g., red meat, seafood) While not a direct drug interaction, allopurinol is used to treat gout. Eating foods high in.
Patient information leaflet
האם אני יכול לקחת אלופורינול ומירטאזאפין יחד?
Water / Fluids It is important to drink plenty of fluids (at least 2 to... This helps to prevent the formation of kidney stones and ensures the medicine works correctly to flush uric acid from your system. Purine-rich foods (e.g., red meat, seafood) While not a direct drug interaction, allopurinol is used to treat gout. Eating foods high in.
Patient information leaflet
האם אני יכול לקחת אלופורינול ורוזובסטטין יחד?
Water / Fluids It is important to drink plenty of fluids (at least 2 to... This helps to prevent the formation of kidney stones and ensures the medicine works correctly to flush uric acid from your system. Purine-rich foods (e.g., red meat, seafood) While not a direct drug interaction, allopurinol is used to treat gout. Eating foods high in.
Patient information leaflet
האם אני יכול לקחת ביוטין וויטמין D יחד?
Raw egg whites Consuming large amounts of raw egg whites over a long period can prevent your body from absorbing biotin. This is because raw egg whites contain a protein called avidin that binds to biotin. Cooked eggs do not cause this issue. Using other medicines T... Our Medicines Interaction Checker helps you check whether your prescriptions,.
Patient information leaflet
האם אני יכול לקחת פטריית האריה ומאצ'ה יחד?
Caffeine Matcha is very high in caffeine. You should be cautious about consuming other caffeinated drinks (like coffee or energy drinks) alongside it, as this can lead to jitteriness, increased heart rate, and difficulty sleeping. Iron-rich foods The tannins in matcha can bind to iron from plant-based foods (non-heme iron), making it harder for.
Patient information leaflet
דיאטת דוקאן
The Dukan diet is a weight loss plan devised by French doctor, Pierre Dukan. What is the Dukan diet. The Dukan diet was. It is one of the high-protein diets in which both fats and carbohydrates are restricted. This is unlike the Atkins diet , ketogenic diet, and other low-carbohydrate:high-fat (LCHF) diets, in which fat is not restricted. The.
קריאה נוספת והפניות
- purine rich element binding protein A; MedlinePlus, National Library of Medicine.
- Brown N, Burgess T, Forbes R, McGillivray G, Kornberg A, Mandelstam S, Stark Z. 5q31.3 Microdeletion syndrome: clinical and molecular characterization of two further cases. Am J Med Genet A. 2013 Oct;161A(10):2604-8. doi: 10.1002/ajmg.a.36108. Epub 2013 Aug 15.
- Hokkanen S, Feldmann HM, Ding H, Jung CK, Bojarski L, Renner-Muller I, Schuller U, Kretzschmar H, Wolf E, Herms J. Lack of Pur-alpha alters postnatal brain development and causes megalencephaly. Hum Mol Genet. 2012 Feb 1;21(3):473-84. doi: 10.1093/hmg/ddr476. Epub 2011 Oct 18.
- Hosoki K, Ohta T, Natsume J, Imai S, Okumura A, Matsui T, Harada N, Bacino CA, Scaglia F, Jones JY, Niikawa N, Saitoh S. Clinical phenotype and candidate genes for the 5q31.3 microdeletion syndrome. Am J Med Genet A. 2012 Aug;158A(8):1891-6. doi: 10.1002/ajmg.a.35439. Epub 2012 Jun 18.
- Lalani SR, Zhang J, Schaaf CP, Brown CW, Magoulas P, Tsai AC, El-Gharbawy A, Wierenga KJ, Bartholomew D, Fong CT, Barbaro-Dieber T, Kukolich MK, Burrage LC, Austin E, Keller K, Pastore M, Fernandez F, Lotze T, Wilfong A, Purcarin G, Zhu W, Craigen WJ, McGuire M, Jain M, Cooney E, Azamian M, Bainbridge MN, Muzny DM, Boerwinkle E, Person RE, Niu Z, Eng CM, Lupski JR, Gibbs RA, Beaudet AL, Yang Y, Wang MC, Xia F. Mutations in PURA cause profound neonatal hypotonia, seizures, and encephalopathy in 5q31.3 microdeletion syndrome. Am J Hum Genet. 2014 Nov 6;95(5):579-83. doi: 10.1016/j.ajhg.2014.09.014. Epub 2014 Oct 16.
- Shimojima K, Isidor B, Le Caignec C, Kondo A, Sakata S, Ohno K, Yamamoto T. A new microdeletion syndrome of 5q31.3 characterized by severe developmental delays, distinctive facial features, and delayed myelination. Am J Med Genet A. 2011 Apr;155A(4):732-6. doi: 10.1002/ajmg.a.33891. Epub 2011 Mar 15.
- Tanaka AJ, Bai R, Cho MT, Anyane-Yeboa K, Ahimaz P, Wilson AL, Kendall F, Hay B, Moss T, Nardini M, Bauer M, Retterer K, Juusola J, Chung WK. De novo mutations in PURA are associated with hypotonia and developmental delay. Cold Spring Harb Mol Case Stud. 2015 Oct;1(1):a000356. doi: 10.1101/mcs.a000356.
- Weber J, Bao H, Hartlmuller C, Wang Z, Windhager A, Janowski R, Madl T, Jin P, Niessing D. Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha. Elife. 2016 Jan 8;5:e11297. doi: 10.7554/eLife.11297.
- White MK, Johnson EM, Khalili K. Multiple roles for Puralpha in cellular and viral regulation. Cell Cycle. 2009 Feb 1;8(3):1-7. doi: 10.4161/cc.8.3.7585. Epub 2009 Feb 10.
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