recombination activating 1
עודכן לאחרונה 18 Aug 2020
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ה RAG1 gene provides instructions for making a member of a group of proteins called the RAG complex. This complex is active in immune system cells (lymphocytes) called B cells and T cells. These cells have special proteins on their surface that recognise foreign invaders and help protect the body from infection. These proteins need to be diverse to be able to recognise a wide variety of substances. The genes from which these proteins are made contain segments known as variable (V), diversity (D), and joining (J) segments. During protein production within lymphocytes, these gene segments are rearranged in different combinations to increase variability of the resulting proteins. The RAG complex is involved in this process, which is known as V(D)J recombination.
Normal function
ה RAG1 gene provides instructions for making a member of a group of proteins called the RAG complex. This complex is active in immune system cells (lymphocytes) called B cells and T cells. These cells have special proteins on their surface that recognise foreign invaders and help protect the body from infection. These proteins need to be diverse to be able to recognise a wide variety of substances. The genes from which these proteins are made contain segments known as variable (V), diversity (D), and joining (J) segments. During protein production within lymphocytes, these gene segments are rearranged in different combinations to increase variability of the resulting proteins. The RAG complex is involved in this process, which is known as V(D)J recombination.
During V(D)J recombination, the RAG complex attaches (binds) to a section of DNA called a recombination signal sequence (RSS), which is next to a V, D, or J segment. The RAG complex makes small cuts in the DNA between the segment and the RSS so the segment can be separated and moved to a different area in the gene. This process of DNA rearrangement within B cells and T cells is repeated multiple times in different areas so that the V, D, and J segments are arranged in various combinations. The variety of proteins produced throughout life following V(D)J recombination provides greater recognition of foreign invaders and allows the body to fight infection efficiently.
Conditions referring to this gene or chromosome
Other names
MGC43321
RAG-1
recombination activating gene 1
recombination activating protein 1
RING finger protein 74
RNF74
V(D)J recombination-activating protein 1
Related patient information and medicines
Patient information leaflet
נוגדי קרישה
Anticoagulants are medicines that prevent the blood from clotting as quickly or as effectively as normal. Some people call anticoagulants blood thinners. However, the blood is not actually made any thinner - it just does not clot so easily whilst you take an anticoagulant. Anticoagulants are used to treat and prevent blood clots forming in blood.
Patient information leaflet
בדיקות קרישת דם
Blood clotting tests are used to diagnose and assess bleeding problems and to monitor people who take warfarin or other anticoagulant medicines. You may be advised to have blood clotting tests: If you have a suspected bleeding disorder. For example, if you bleed a lot after cuts, or if you bruise easily. If you have certain liver diseases that can.
Patient information leaflet
האם אני יכול לקחת קלופידוגרל וגבאפנטין יחד?
There are no known significant interactions between clopidogrel and gabapentin. It is generally conside... Why this happens Clopidogrel and gabapentin are processed by the body using different pathways. Clopidogrel is activated by liver enzymes (specifically CYP2C19), while gabapentin is not processed by the liver at all and is removed from the.
Patient information leaflet
האם אני יכול לקחת מאיטאקה וזנב הודו יחד?
יש no known harmful interactions between maitake and turkey tail mushrooms. However, because both ca... Why this happens Both maitake (Grifola frondosa) and turkey tail (Trametes versicolor) contain complex sugars called beta-glucans. These compounds work in a similar way by activating certain immune cells (like natural killer cells and.
Patient information leaflet
האם אני יכול לקחת קלופידוגרל ופנופיברט יחד?
Taking clopidogrel and fenofibrate together may slightly increase the risk of bleeding or bruising. While this combination is often prescribed together for heart health, it requires careful monitoring. Simply search for your med... Disclaimer This information is for general educational purposes only and should not be relied upon as a substitute.
Patient information leaflet
חיסון 6-ב-1
ה חיסון 6-ב-1 used to be given as the 3-in-1 vaccine DTaP along with the פוליו vaccine which was given by mouth, but has gradually been extended so that it now. It is given in one single injection into the thigh from one single syringe. This leaflet explains when this vaccine is given and why. It also explains which components of the 6-in-1.
קריאה נוספת והפניות
- recombination activating 1; MedlinePlus, National Library of Medicine.
- Bai X, Liu J, Zhang Z, Liu C, Zhang Y, Tang W, Dai R, Wu J, Tang X, Zhang Y, Ding Y, Jiang L, Zhao X. Clinical, immunologic, and genetic characteristics of RAG mutations in 15 Chinese patients with SCID and Omenn syndrome. Immunol Res. 2016 Apr;64(2):497-507. doi: 10.1007/s12026-015-8723-4.
- Carmona LM, Schatz DG. New insights into the evolutionary origins of the recombination-activating gene proteins and V(D)J recombination. FEBS J. 2017 Jun;284(11):1590-1605. doi: 10.1111/febs.13990. Epub 2017 Jan 6.
- Cassani B, Poliani PL, Moratto D, Sobacchi C, Marrella V, Imperatori L, Vairo D, Plebani A, Giliani S, Vezzoni P, Facchetti F, Porta F, Notarangelo LD, Villa A, Badolato R. Defect of regulatory T cells in patients with Omenn syndrome. J Allergy Clin Immunol. 2010 Jan;125(1):209-16. doi: 10.1016/j.jaci.2009.10.023.
- Notarangelo LD, Kim MS, Walter JE, Lee YN. Human RAG mutations: biochemistry and clinical implications. Nat Rev Immunol. 2016 Apr;16(4):234-46. doi: 10.1038/nri.2016.28. Epub 2016 Mar 21.
- Ru H, Chambers MG, Fu TM, Tong AB, Liao M, Wu H. Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures. Cell. 2015 Nov 19;163(5):1138-1152. doi: 10.1016/j.cell.2015.10.055. Epub 2015 Nov 5.
- Somech R, Simon AJ, Lev A, Dalal I, Spirer Z, Goldstein I, Nagar M, Amariglio N, Rechavi G, Roifman CM. Reduced central tolerance in Omenn syndrome leads to immature self-reactive oligoclonal T cells. J Allergy Clin Immunol. 2009 Oct;124(4):793-800. doi: 10.1016/j.jaci.2009.06.048. Epub 2009 Sep 19.
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