Can I take Atorvastatin and Clarithromycin together?

למה זה קורה

Clarithromycin blocks a specific enzyme in the liver (CYP3A4) that is responsible for breaking down atorvastatin. When this enzyme is blocked, atorvastatin builds up to dangerous levels in the body.

You should not take these two medicines together. If you are prescribed clarithromycin, your doctor will usually advise you to temporarily stop taking atorvastatin until the course of antibiotics is finished. If you must take both, your doctor may prescribe a much lower dose of atorvastatin and monitor you closely. Seek medical help immediately if you experience unexplained muscle pain.

Drug-drug interaction

Do not take these two medicines together. Clarithromycin significantly increases the levels of atorvastatin in your blood, which can cause severe muscle breakdown (rhabdomyolysis) and kidney damage. Atorvastatin must be paused while taking this antibiotic.

הריון

Do not atorvastatin if you are pregnant or planning to become pregnant. It can cause serious harm to an unborn baby. Use effective contraception while taking it and for one month after stopping.

Muscle pain or weakness - atorvastatin

You must report any unexplained muscle pain, tenderness, or weakness to a doctor immediately, especially if you also feel unwell or have a fever. This can be a sign of a rare but serious muscle breakdown.

מיץ אשכוליות

Grapefruit juice contains compounds that can increase the level of atorvastatin in your blood. This can increase your risk of side effects, such as muscle pain or damage. You should avoid drinking large quantities (more than 1.2 litres per day), but it is safest to avoid grapefruit juice altogether while taking this medicine.

אלכוהול

Drinking large amounts of alcohol while taking atorvastatin can increase the risk of liver problems. It is recommended to stay within the low-risk weekly guidelines (no more than 14 units per week).

מזון (כללי)

Clarithromycin can be taken with or without food. However, if you find that the medicine upsets your stomach, taking it with a meal or a snack may help reduce these side effects.

Taking multiple medicines? Our בודק אינטראקציות בין תרופות helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

הבהרה

מידע זה מיועד למטרות חינוכיות כלליות בלבד ואין להסתמך עליו כתחליף לייעוץ רפואי מקצועי. תמיד יש להתייעץ עם רופא המשפחה, רוקח או איש מקצוע רפואי מוסמך אחר לפני קבלת החלטות לגבי התרופות שלך. נסיבות אישיות עשויות להשתנות, ורק איש מקצוע רפואי שמכיר את ההיסטוריה הרפואית שלך יכול לספק הנחיות מותאמות אישית.