Can I take Ibuprofen and Pregabalin together?

Why this happens

Both medications can affect the central nervous system, leading to an additive effect on drowsiness. Additionally, both drugs can independently cause the body to hold onto extra fluid (peripheral oedema), and taking them together may make this more likely.

What you should do

It is generally acceptable to take these together if prescribed or recommended by a healthcare professional, but you should use caution. Monitor yourself for increased sleepiness or significant swelling in your ankles or hands. It is best to avoid or strictly limit alcohol while taking these medicines, as alcohol will worsen the drowsiness. Do not drive or operate machinery until you are certain the combination does not make you feel too dizzy or tired.

Important precautions

Mental health disorders

Pregabalin can cause suicidal thoughts or an urge to self-harm. You must seek medical help immediately if your mood changes or you have thoughts of hurting yourself.

Asthma

Do not take ibuprofen if you have asthma, as it can cause a life-threatening worsening of your breathing or a severe allergic reaction.

Respiratory depression

Pregabalin can cause severe breathing problems, especially if you already have lung disease or if you take it with other medicines that cause drowsiness or contain opioids.

Stomach ulcers or bleeding

Avoid ibuprofen if you have ever had a stomach ulcer, perforation, or bleeding, as it can cause serious damage to the stomach lining.

Pregnancy

Pregabalin must not be used during pregnancy unless specifically advised by a specialist, as it may increase the risk of birth defects. Effective contraception must be used during treatment.

Pregnancy (third trimester)

Do not take ibuprofen if you are more than 6 months pregnant, as it can cause serious heart and kidney problems in the unborn baby and complications during birth.

Drug dependence and misuse

Pregabalin can lead to dependence and addiction. Only take the dose prescribed and do not stop taking it suddenly, as this can cause severe withdrawal symptoms.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol while taking ibuprofen. Combining alcohol with non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen increases the risk of irritation to your stomach lining and can lead to stomach ulcers or bleeding.

It is best to avoid or strictly limit alcohol while taking pregabalin. Combining alcohol with this medicine can significantly increase side effects such as extreme sleepiness, dizziness, and blurred vision. It can also increase the risk of breathing problems.

Food (General)

It is recommended to take ibuprofen with food or a glass of milk to reduce the risk of stomach upset or indigestion.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.