Can I take Maitake and Reishi together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
Taking maitake and reishi together may increase the risk of bruising or bleeding. Both mushrooms have properties that can slow down blood clotting. Additionally, both may lower blood sugar levels, which could lead to symptoms of low blood sugar (hypoglycaemia) such as dizziness or shakiness.
Why this happens
Both maitake and reishi have 'antiplatelet' effects, meaning they make blood cells less sticky and less likely to form clots. When used together, this effect is additive. They also both possess glucose-lowering properties, which can further reduce blood sugar levels when combined.
What you should do
It is generally safe for healthy individuals to take these together in moderate amounts, but you should use caution. If you are scheduled for surgery, stop taking both at least two weeks beforehand. If you take blood-thinning medications (like warfarin or aspirin) or diabetes medication, speak to your doctor before combining these supplements, as your dosages may need adjusting.
Important precautions
Bleeding disorders or surgery
Both maitake and reishi may slow blood clotting and increase the risk of bleeding. You must stop taking these at least 2 weeks before any scheduled surgery. Use with caution if you are taking blood-thinning medications like warfarin or aspirin.
Diabetes
These supplements can lower blood sugar levels. If you are taking insulin or other diabetes medications, monitor your blood sugar closely as your dose may need adjustment to prevent hypoglycaemia (dangerously low blood sugar).
Auto-immune conditions (e.g., multiple sclerosis, lupus, rheumatoid arthritis)
These supplements can increase immune system activity, which may worsen the symptoms of autoimmune diseases. Avoid use if you have these conditions.
Low blood pressure (Hypotension)
These supplements may lower blood pressure. If you already have low blood pressure or take medication to control high blood pressure, they could cause your blood pressure to drop too low.
Food and drink warnings
Alcohol
It is best to avoid or strictly limit alcohol when taking these supplements. Both Maitake and Reishi can have effects on the liver, and combining them with alcohol may increase the risk of liver strain or damage. Additionally, Reishi can have sedative effects which alcohol may intensify.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Drug interactions checker
Can I take Warfarin and Aspirin together?
Taking warfarin and aspirin together significantly increases your risk of serious bleeding. This includes internal bleeding, such as in the stomach or brain, as well as bleeding that is hard to stop from minor cuts or injuries.

Drug interactions checker
Can I take Ashwagandha and Vitamin B12 together?
There are no known clinical interactions between ashwagandha and vitamin B12. It is generally considered safe to take these two supplements together.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published
Join the conversation
Share your thoughts or experiences with others in our patient communities.

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.
More in drug interactions checker
- Can I take Apixaban and Tramadol together?
- Can I take Atorvastatin and Maitake together?
- Can I take Colecalciferol and Esomeprazole together?
- Can I take Colecalciferol and Tizanidine together?
- Can I take Colecalciferol and Trazodone together?
- Can I take Collagen and Omega-3 together?
- Can I take Doxadura and Losartan together?
- Can I take Fish oil and Vitamin D together?
- Can I take Hydroxychloroquine and Naproxen together?
- Can I take Ibuprofen and Ropinirole together?
- Can I take Iron supplements and Pregabalin together?
- Can I take Lansoprazole and Ibuprofen together?
- Can I take Loratadine and Ibuprofen together?
- Can I take Losartan and Turmeric together?
- Can I take Naproxen and Tramadol together?
- Can I take Omeprazole and Ibuprofen together?
- Can I take Omeprazole and Sertraline together?
- Can I take Sertraline and Fluoxetine together?
- Can I take Sildenafil and Grapefruit together?
- Can I take St John's wort and Sertraline together?