Hepatic lipase deficiency
עודכן לאחרונה 18 Aug 2020
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Hepatic lipase deficiency is a disorder that affects the body's ability to break down fats (lipids). People with this disorder have increased amounts of certain fats, known as triglycerides and cholesterol, in the blood. These individuals also have increased amounts of molecules known as high-density lipoproteins (HDLs) and decreased amounts of molecules called low-density lipoproteins (LDL). These molecules transport triglycerides and cholesterol throughout the body. In people with hepatic lipase deficiency, the LDL molecules are often abnormally large.
תיאור
Hepatic lipase deficiency is a disorder that affects the body's ability to break down fats (lipids). People with this disorder have increased amounts of certain fats, known as triglycerides and cholesterol, in the blood. These individuals also have increased amounts of molecules known as high-density lipoproteins (HDLs) and decreased amounts of molecules called low-density lipoproteins (LDL). These molecules transport triglycerides and cholesterol throughout the body. In people with hepatic lipase deficiency, the LDL molecules are often abnormally large.
Normally, high levels of HDL (known as "good cholesterol") and low levels of LDL (known as "bad cholesterol") are protective against an accumulation of fatty deposits on the artery walls (atherosclerosis) and heart disease. However, some individuals with hepatic lipase deficiency, who have this imbalance of HDL and LDL, develop atherosclerosis and heart disease in mid-adulthood, while others do not. It is unknown whether people with hepatic lipase deficiency have a greater risk of developing atherosclerosis or heart disease than individuals in the general population. Similarly, it is unclear how increased blood triglycerides and cholesterol levels affect the risk of atherosclerosis and heart disease in people with hepatic lipase deficiency.
Inheritance patterns
The source lists the following possible inheritance patterns: Autosomal recessive. More than one pattern can apply in different cases.
Related genes
Other names
HL deficiency
Hyperlipidemia due to hepatic triglyceride lipase deficiency
LIPC deficiency
Related patient information and medicines
Patient information leaflet
שחמת
שחמת is a serious condition where normal liver tissue is replaced by scar tissue (fibrosis). It tends to progress slowly and often does not cause symptoms in its early stages. However, as the function of the liver gradually becomes worse, serious problems can develop. In the UK, the two commonest causes of cirrhosis are alcohol drinking above.
Patient information leaflet
כשל כבד
These include paracetamol poisoning, infections (for example, הפטיטיס B או hepatitis C), acute fatty. For some people with liver failure the cause is not known. What are the functions of the liver. A healthy liver does a number of essential functions for the body. These include: Removing harmful substances from the body, including alcohol..
Patient information leaflet
תת-ספיגה במערכת העיכול
Gastrointestinal malabsorption syndrome means a failure to fully absorb digested foods from the gut (bowel) into your body. There are many different causes. Prolonged intestinal malabsorption may cause problems because of a lack of carbohydrates, proteins, fats, minerals and vitamins that are essential to keep you healthy. The treatment will.
Patient information leaflet
חסר באלפא-1 אנטיטריפסין
חסר באלפא-1 אנטיטריפסין is an inherited genetic condition. A genetic condition is one that can be passed on from parents through genes. In alpha-1 antitrypsin deficiency the result of a genetic abnormality leads to lung and, in some people, liver damage. Lung symptoms are the most common and include shortness of breath, cough and wheezing..
Patient information leaflet
האם אני יכול לקחת פנקריאטין וליקסיאנה יחד?
There are no known ... Pancreatin works locally in the gut to help digest food, while Lixiana is absorbed into the bloodstream to prevent blood clots. Why this happens Pancreatin consists of digestive enzymes (lipase, protease, and amylase) that break down fats, proteins, and starches in the digestive tract. Lixiana is an oral anticoagulant (blood.
Patient information leaflet
האם אני יכול לקחת לקטולוז ורופינירול יחד?
Alcohol can cause dehydration, which may worsen the constipation you are trying to treat. Additionally, if you are taking lactulose for liver disease (hepatic encephalopathy), alcohol must be avoided entirely as it can significantly worsen your condition. Water and Fluids It is essential to drink plenty of fluids (such as water) while taking.
קריאה נוספת והפניות
- Hepatic lipase deficiency; MedlinePlus, National Library of Medicine.
- Chatterjee C, Sparks DL. Hepatic lipase, high density lipoproteins, and hypertriglyceridemia. Am J Pathol. 2011 Apr;178(4):1429-33. doi: 10.1016/j.ajpath.2010.12.050. Epub 2011 Feb 26.
- Kobayashi J, Miyashita K, Nakajima K, Mabuchi H. Hepatic Lipase: a Comprehensive View of its Role on Plasma Lipid and Lipoprotein Metabolism. J Atheroscler Thromb. 2015;22(10):1001-11. doi: 10.5551/jat.31617. Epub 2015 Jul 21.
- Tilly-Kiesi M, Schaefer EJ, Knudsen P, Welty FK, Dolnikowski GG, Taskinen MR, Lichtenstein AH. Lipoprotein metabolism in subjects with hepatic lipase deficiency. Metabolism. 2004 Apr;53(4):520-5. doi: 10.1016/j.metabol.2003.10.020.
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