ATP binding cassette subfamily A member 3
עודכן לאחרונה 18 Aug 2020
עומד בהנחיות העריכה של Patient
- הורדהורד
- שתף
- Language
- דיון
- גרסת שמע
- הוסף למקורות מועדפים בגוגל
ה ABCA3 gene provides instructions for making a protein involved in surfactant production. Surfactant is a mixture of certain fats (called phospholipids) and proteins that lines the lung tissue and makes breathing easy. Without normal surfactant, the tissue surrounding the air sacs in the lungs (the alveoli) sticks together after exhalation (because of a force called surface tension), causing the alveoli to collapse. As a result, filling the lungs with air on each breath becomes very difficult, and delivery of oxygen to the body is impaired.
Normal function
ה ABCA3 gene provides instructions for making a protein involved in surfactant production. Surfactant is a mixture of certain fats (called phospholipids) and proteins that lines the lung tissue and makes breathing easy. Without normal surfactant, the tissue surrounding the air sacs in the lungs (the alveoli) sticks together after exhalation (because of a force called surface tension), causing the alveoli to collapse. As a result, filling the lungs with air on each breath becomes very difficult, and delivery of oxygen to the body is impaired.
The ABCA3 protein is found in the membrane that surrounds lamellar bodies, which are the cellular structures in which the phospholipids and proteins that make up surfactant are packaged. The ABCA3 protein transports phospholipids into the lamellar bodies where they interact with surfactant proteins to form surfactant. The ABCA3 protein also appears to be involved in the formation of normal lamellar bodies. In addition to packaging, lamellar bodies are important for the correct processing of surfactant proteins, which is necessary for the proteins to mature and become functional.
Conditions referring to this gene or chromosome
Other names
ABC transporter 3
ABC-C
ABC-C transporter
ABC3
ABCA3_HUMAN
ATP-binding cassette sub-family A member 3
ATP-binding cassette transporter 3
ATP-binding cassette, sub-family A (ABC1), member 3
SMDP3
Related patient information and medicines
Patient information leaflet
האם אני יכול לקחת אטורבסטטין ותוספי סיבים יחד?
This means the statin may not work as well to lower your cholesterol. Why this happens Fibre supplements (like psyllium husk or methylcellulose) can bind to the atorvastatin in your stomach or intestines, preventing it from entering your bloodstream. What you should do You do not need to stop taking fibre, but you should separate the doses. Our.
Patient information leaflet
מערכת החיסון
This leaflet gives a brief overview of the מערכת חיסונית and how it works. A person with a weak immune system might have difficulty fighting off infections. In autoimmune diseases the body is unable to tell what is its own and what is foreign, so it attacks itself. Autoimmune diseases can attack any part of the body - eg, type 1 diabetes.
Patient information leaflet
האם אני יכול לקחת ביסופרולול ותוספי סיבים יחד?
Taking them without enough liquid can cause the supplement to swell a... Using other medicines Taking multiple medicines. Our בודק אינטראקציות בין תרופות helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do.
Patient information leaflet
מחלת כליות פוליציסטית
The most common type of PKD is an inherited condition called autosomal dominant polycystic kidney disease (ADPKD). About half of ADPKD cases lead to kidney failure requiring dialysis or a kidney transplant. A cyst is a fluid-filled sac. Polycystic kidney disease is a condition where many cysts develop in the kidneys. Note : it is common for.
Patient information leaflet
האם אני יכול לקחת אטורבסטטין וביוטין יחד?
There is no known interaction between atorvastatin and biotin. It is generally considered safe to take these two together. Why this happens Atorvastatin is processed by specific liver enzymes (CYP3A4), while biotin (Vitamin B7) is a water-soluble vitamin that uses different pathways for absorption and processing. They do not interfere with each.
Patient information leaflet
כולנגיטיס ביליארי ראשוני
Primary biliary cholangitis (PBC) is a condition that slowly damages the bile ducts in your liver, leading to liver damage and, sometimes, liver scarring (cirrhosis). Primary biliary cholangitis (PBC) is an auto-immune condition in which your immune system gradually destroys the tiny tubes (bile ducts) which take bile from the liver to the gut.
קריאה נוספת והפניות
- ATP binding cassette subfamily A member 3; MedlinePlus, National Library of Medicine.
- Brasch F, Schimanski S, Muhlfeld C, Barlage S, Langmann T, Aslanidis C, Boettcher A, Dada A, Schroten H, Mildenberger E, Prueter E, Ballmann M, Ochs M, Johnen G, Griese M, Schmitz G. Alteration of the pulmonary surfactant system in full-term infants with hereditary ABCA3 deficiency. Am J Respir Crit Care Med. 2006 Sep 1;174(5):571-80. doi: 10.1164/rccm.200509-1535OC. Epub 2006 May 25.
- Cheong N, Zhang H, Madesh M, Zhao M, Yu K, Dodia C, Fisher AB, Savani RC, Shuman H. ABCA3 is critical for lamellar body biogenesis in vivo. J Biol Chem. 2007 Aug 17;282(33):23811-7. doi: 10.1074/jbc.M703927200. Epub 2007 May 31.
- Matsumura Y, Ban N, Inagaki N. Aberrant catalytic cycle and impaired lipid transport into intracellular vesicles in ABCA3 mutants associated with nonfatal pediatric interstitial lung disease. Am J Physiol Lung Cell Mol Physiol. 2008 Oct;295(4):L698-707. doi: 10.1152/ajplung.90352.2008. Epub 2008 Aug 1.
- Matsumura Y, Ban N, Ueda K, Inagaki N. Characterization and classification of ATP-binding cassette transporter ABCA3 mutants in fatal surfactant deficiency. J Biol Chem. 2006 Nov 10;281(45):34503-14. doi: 10.1074/jbc.M600071200. Epub 2006 Sep 7.
הצטרפו לשיחה
שתפו את מחשבותיכם או חוויותיכם עם אחרים ב קהילות המטופלים שלנו.
שאלו, שתפו, התחברו.
עיין בדיונים, שאל שאלות ושתף חוויות במאות נושאים בריאותיים.
הירשמו לניוזלטר של פיישנט
המנה השבועית שלך של עצות בריאות ברורות ואמינות - נכתבה כדי לעזור לך להרגיש מעודכן, בטוח ובשליטה.
על ידי הרשמה אתה מקבל את שלנו מדיניות הפרטיות שלנו. באפשרותך לבטל את המנוי בכל עת. לעולם לא נמכור את הנתונים שלך.