דלג לתוכן הראשי

caspase recruitment domain family member 9

עודכן לאחרונה 18 Aug 2020

עומד בהנחיות העריכה של Patient

ה CARD9 gene provides instructions for making an immune system protein that is involved in the body's defense against fungal infections and is particularly important for fighting infection by a fungus called קנדידה. When the immune system recognizes קנדידה, it generates cells called Th17 cells. These cells produce signaling molecules (cytokines) called the interleukin-17 (IL-17) family as part of an immune process called the IL-17 pathway. The IL-17 pathway creates inflammation, sending other cytokines and white blood cells that fight foreign invaders and promote tissue repair. In addition, the IL-17 pathway promotes the production of certain antimicrobial protein segments (peptides) that control growth of קנדידה on the surface of mucous membranes.

Normal function

ה CARD9 gene provides instructions for making an immune system protein that is involved in the body's defense against fungal infections and is particularly important for fighting infection by a fungus called קנדידה. When the immune system recognizes קנדידה, it generates cells called Th17 cells. These cells produce signaling molecules (cytokines) called the interleukin-17 (IL-17) family as part of an immune process called the IL-17 pathway. The IL-17 pathway creates inflammation, sending other cytokines and white blood cells that fight foreign invaders and promote tissue repair. In addition, the IL-17 pathway promotes the production of certain antimicrobial protein segments (peptides) that control growth of קנדידה on the surface of mucous membranes.

In its role in defending against קנדידה on the mucous membranes and skin, the CARD9 protein passes along signals from other types of immune system proteins. Each of these proteins recognizes a different component of the קנדידה cell wall to trigger the production of Th17 cells and launch the immune response.

In addition to its role in protecting mucous membranes from fungal infection, the CARD9 protein is also important in recruiting neutrophils (immune cells that have strong anti-fungal activity) from the blood to protect the brain and other organs from fungal infection.

Conditions referring to this gene or chromosome

Other names

caspase recruitment domain family, member 9

hCARD9

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  • 18 Aug 2020 | הגרסה האחרונה
  • 1 Sept 2016 | פורסם במקור

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