DEP domain containing 5, GATOR1 subcomplex subunit
עודכן לאחרונה 4 Aug 2025
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The DEPDC5 gene provides instructions for making a protein that is part of a larger group of proteins (a complex) called GATOR1. This complex is made up of the DEPDC5 protein and proteins made from two other genes: NPRL2 and NPRL3. GATOR1 is found in cells throughout the body, where it regulates a signaling pathway called the mTOR pathway. The mTOR pathway is involved in cell growth and division (proliferation) and the creation (synthesis) of new proteins. In the brain, the mTOR pathway regulates many processes, including the growth and development of nerve cells and their ability to change and adapt over time (plasticity).
Normal function
The DEPDC5 gene provides instructions for making a protein that is part of a larger group of proteins (a complex) called GATOR1. This complex is made up of the DEPDC5 protein and proteins made from two other genes: NPRL2 and NPRL3. GATOR1 is found in cells throughout the body, where it regulates a signaling pathway called the mTOR pathway. The mTOR pathway is involved in cell growth and division (proliferation) and the creation (synthesis) of new proteins. In the brain, the mTOR pathway regulates many processes, including the growth and development of nerve cells and their ability to change and adapt over time (plasticity).
The GATOR1 complex blocks this pathway by stopping (inhibiting) the activity of a complex called mTOR complex 1 (mTORC1) that is integral to the mTOR pathway.
Conditions referring to this gene or chromosome
Other names
DEE111
DEP domain containing 5
DEP.5
FFEVF
FFEVF1
FPEVF
KIAA0645
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קריאה נוספת והפניות
- DEP domain containing 5, GATOR1 subcomplex subunit; MedlinePlus, National Library of Medicine.
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- Kurahashi H, Hirose S. Autosomal Dominant Sleep-Related Hypermotor (Hyperkinetic) Epilepsy. 2002 May 16 [updated 2023 Mar 23]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK1169/
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