NF2, moesin-ezrin-radixin like (MERLIN) tumour suppressor
עודכן לאחרונה 17 אפריל 2023
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ה NF2 gene provides instructions for the production of a protein called merlin, also known as schwannomin. This protein is made in the nervous system, particularly in specialized cells called Schwann cells that wrap around and insulate nerves.
Normal function
ה NF2 gene provides instructions for the production of a protein called merlin, also known as schwannomin. This protein is made in the nervous system, particularly in specialized cells called Schwann cells that wrap around and insulate nerves.
Merlin helps regulate several key signaling pathways that are important for controlling cell shape, cell growth, and the attachment of cells to one another (cell adhesion). This protein functions as a tumour suppressor, preventing cells from growing and dividing too fast or in an uncontrolled way.
Conditions referring to this gene or chromosome
Other names
ACN
BANF
MERL_HUMAN
merlin
moesin-ezrin-radixin-like protein
SCH
schwannomerlin
schwannomin
Related patient information and medicines
Patient information leaflet
נוירומה אקוסטית
א נוירומה אקוסטית is a rare non-cancerous tumour in the brain. The tumour grows on a nerve in the b... In fewer than 1 in 10 people, an acoustic neuroma is caused by neurofibromatosis type 2 (NF2). NF2 is a very rare genetic disorder that causes non-cancerous (benign) tumours of the nervous system. People with NF2 can also develop benign tumours.
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סרטן השד
אם סרטן השד מטופל? diagnosed at an early stage, less treatment may be needed and it is more likely to be effective. In general, the more advanced the cancer (the more it has grown and spread), the less chance that treatment will be curative. However, treatments are improving all the time and they can often slow the progress of the cancer. Breast.
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סרטן כבד ראשוני
ב secondary liver cancer, ה cancer spreads from another part of the body to the liver. In the UK, most cases develop as a complication of scarring of the liver (cirrhosis). Surgery to remove the cancer is an option in a small number of cases and, if it is possible, gives the best chance of a cure. In the UK, primary liver cancer is uncommon..
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סרטן הכליה
אם סרטן הכליה is diagnosed at an early stage, there is a good chance of a cure. Renal cell cancer This type of cancer develops from a cell in a kidney tubule, which becomes cancerous (malignant). The cancer grows and forms into a tumour within the kidney. As the tumour grows: The affected kidney tends to become larger. In time the tumour may.
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פוליפים באף
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Patient information leaflet
טיפול בסרטן
אפשרויות טיפול vary, depending on the type of cancer and how far it has grown and spread. The main types are surgery, chemotherapy and radiotherapy. What are the treatment options for cancer. Treatment options vary, depending on the type of cancer and how far it has grown and spread. See the separate leaflets on the specific cancers for more.
קריאה נוספת והפניות
- NF2, moesin-ezrin-radixin like (MERLIN) tumour suppressor; MedlinePlus, National Library of Medicine.
- Ahronowitz I, Xin W, Kiely R, Sims K, MacCollin M, Nunes FP. Mutational spectrum of the NF2 gene: a meta-analysis of 12 years of research and diagnostic laboratory findings. Hum Mutat. 2007 Jan;28(1):1-12. doi: 10.1002/humu.20393.
- Cooper J, Giancotti FG. Molecular insights into NF2/Merlin tumor suppressor function. FEBS Lett. 2014 Aug 19;588(16):2743-52. doi: 10.1016/j.febslet.2014.04.001. Epub 2014 Apr 12.
- Hadfield KD, Newman WG, Bowers NL, Wallace A, Bolger C, Colley A, McCann E, Trump D, Prescott T, Evans DG. Molecular characterisation of SMARCB1 and NF2 in familial and sporadic schwannomatosis. J Med Genet. 2008 Jun;45(6):332-9. doi: 10.1136/jmg.2007.056499. Epub 2008 Feb 19.
- MacCollin M, Willett C, Heinrich B, Jacoby LB, Acierno JS Jr, Perry A, Louis DN. Familial schwannomatosis: exclusion of the NF2 locus as the germline event. Neurology. 2003 Jun 24;60(12):1968-74. doi: 10.1212/01.wnl.0000070184.08740.e0.
- Petrilli AM, Fernandez-Valle C. Role of Merlin/NF2 inactivation in tumor biology. Oncogene. 2016 Feb 4;35(5):537-48. doi: 10.1038/onc.2015.125. Epub 2015 Apr 20.
- Schroeder RD, Angelo LS, Kurzrock R. NF2/merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations. Oncotarget. 2014 Jan 15;5(1):67-77. doi: 10.18632/oncotarget.1557.
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