Ras like without CAAX 1
עודכן לאחרונה 25 Apr 2023
עומד בהנחיות העריכה של Patient
- הורדהורד
- שתף
- Language
- דיון
- גרסת שמע
- הוסף למקורות מועדפים בגוגל
ה RIT1 gene provides instructions for making a protein that helps cells survive during periods of cellular stress, such as unusually high energy demands. As part of a signaling pathway known as the RAS/MAPK pathway, the RIT1 protein relays signals from outside the cell to the cell's nucleus. These signals instruct the cell to grow and divide (proliferate) or to mature and take on specialized functions (differentiate). The RIT1 protein is a GTPase, which means it converts a molecule called GTP into another molecule called GDP. To transmit signals during periods of cellular stress, the RIT1 protein is turned on by attaching (binding) to a molecule of GTP. The RIT1 protein is turned off (inactivated) when it converts the GTP to GDP. When the protein is bound to GDP, it does not relay signals to the cell's nucleus.
Normal function
ה RIT1 gene provides instructions for making a protein that helps cells survive during periods of cellular stress, such as unusually high energy demands. As part of a signaling pathway known as the RAS/MAPK pathway, the RIT1 protein relays signals from outside the cell to the cell's nucleus. These signals instruct the cell to grow and divide (proliferate) or to mature and take on specialized functions (differentiate). The RIT1 protein is a GTPase, which means it converts a molecule called GTP into another molecule called GDP. To transmit signals during periods of cellular stress, the RIT1 protein is turned on by attaching (binding) to a molecule of GTP. The RIT1 protein is turned off (inactivated) when it converts the GTP to GDP. When the protein is bound to GDP, it does not relay signals to the cell's nucleus.
ה RIT1 gene belongs to a class of genes known as oncogenes. When mutated, oncogenes have the potential to cause normal cells to become cancerous. The RIT1 gene is in the Ras family of oncogenes, which also includes three other genes: KRAS, HRAS, and NRAS. These proteins play important roles in cell division, cell differentiation, and the self-destruction of cells (apoptosis).
Conditions referring to this gene or chromosome
Other names
GTP-binding protein Roc1
MGC125864
MGC125865
Ras-like without CAAX 1
ras-like without CAAX protein 1
RIBB
RIT
ROC1
Related patient information and medicines
Patient information leaflet
פריחות ויראליות
Many viral infections can cause a rash in addition to other symptoms. Rashes are very common with viral infections, especially in young children. It is very important to make sure the rash is not part of a serious infection - eg, meningococcal infection which is a bacterial infection and can be associated with meningitis. What is a viral rash. The.
Patient information leaflet
מיקופלסמה גניטליום
Infection of the Fallopian tubes may cause them to become scarred and blocked, leading to tubal infertility. Sexually acquired reactive arthritis (SARA) can occur as a reaction to urethritis in men and women. Epididymo-orchitis may occur in men - this is painful swelling and infection of the testicle (testis) and a tube called the epididymis..
Patient information leaflet
פיטיריאזיס רוזאה
פיטיריאזיס רוזאה is a self-limiting rash, In other words it goes away on its own without any treatment. Although the rash can be quite dramatic, the illness is very mild. What is pityriasis rosea. Pityriasis rosea is a self-limiting rash that can occur both in adults and in children. Pityriasis rosea is more common in children and young adults..
Patient information leaflet
פריחות בעור
There are many different types of skin rashes ו many different causes of skin rashes. Although most פריחות בעור are harmless, חלק do need treatment (which may be tablets, creams or ointments) from your doctor or pharmacist. Some rashes ( especially dark red or purple rashes that don't fade when you press them ) may even need urgent medical.
Patient information leaflet
ליכן פלאנוס
Lichen planus mainly causes an itchy skin rash. In some people it also affects other parts of the body such as the mouth, genitals, nails and hair. Most people get better in 6-12 months. Treatment, commonly with a steroid cream or ointment, often eases the ... What is lichen planus. Lichen planus is a condition that mainly affects the skin to.
Patient information leaflet
תרופות ביולוגיות לדלקת מפרקים שגרונית
Biological medicines are a newer type of medicine, used to ease the symptoms of דלקת מפרקים שגרונית and reduce the damaging effect of the disease on the joints. They are usually prescribed when you have tried o... What are biological medicines. Biological medicines are a group of newer תרופות that are used to ease the symptoms of rheumatoid.
קריאה נוספת והפניות
- Ras like without CAAX 1; MedlinePlus, National Library of Medicine.
- Berger AH, Imielinski M, Duke F, Wala J, Kaplan N, Shi GX, Andres DA, Meyerson M. Oncogenic RIT1 mutations in lung adenocarcinoma. Oncogene. 2014 Aug 28;33(35):4418-23. doi: 10.1038/onc.2013.581. Epub 2014 Jan 27.
- Gomez-Segui I, Makishima H, Jerez A, Yoshida K, Przychodzen B, Miyano S, Shiraishi Y, Husseinzadeh HD, Guinta K, Clemente M, Hosono N, McDevitt MA, Moliterno AR, Sekeres MA, Ogawa S, Maciejewski JP. Novel recurrent mutations in the RAS-like GTP-binding gene RIT1 in myeloid malignancies. Leukemia. 2013 Sep;27(9):1943-6. doi: 10.1038/leu.2013.179. Epub 2013 Jun 14. No abstract available.
- Kouz K, Lissewski C, Spranger S, Mitter D, Riess A, Lopez-Gonzalez V, Luttgen S, Aydin H, von Deimling F, Evers C, Hahn A, Hempel M, Issa U, Kahlert AK, Lieb A, Villavicencio-Lorini P, Ballesta-Martinez MJ, Nampoothiri S, Ovens-Raeder A, Puchmajerova A, Satanovskij R, Seidel H, Unkelbach S, Zabel B, Kutsche K, Zenker M. Genotype and phenotype in patients with Noonan syndrome and a RIT1 mutation. Genet Med. 2016 Dec;18(12):1226-1234. doi: 10.1038/gim.2016.32. Epub 2016 Apr 21.
- Milosavljevic D, Overwater E, Tamminga S, de Boer K, Elting MW, van Hoorn ME, Rinne T, Houweling AC. Two cases of RIT1 associated Noonan syndrome: Further delineation of the clinical phenotype and review of the literature. Am J Med Genet A. 2016 Jul;170(7):1874-80. doi: 10.1002/ajmg.a.37657. Epub 2016 Apr 25.
- Shi GX, Jin L, Andres DA. A rit GTPase-p38 mitogen-activated protein kinase survival pathway confers resistance to cellular stress. Mol Cell Biol. 2011 May;31(10):1938-48. doi: 10.1128/MCB.01380-10. Epub 2011 Mar 28.
- Yaoita M, Niihori T, Mizuno S, Okamoto N, Hayashi S, Watanabe A, Yokozawa M, Suzumura H, Nakahara A, Nakano Y, Hokosaki T, Ohmori A, Sawada H, Migita O, Mima A, Lapunzina P, Santos-Simarro F, Garcia-Minaur S, Ogata T, Kawame H, Kurosawa K, Ohashi H, Inoue S, Matsubara Y, Kure S, Aoki Y. Spectrum of mutations and genotype-phenotype analysis in Noonan syndrome patients with RIT1 mutations. Hum Genet. 2016 Feb;135(2):209-22. doi: 10.1007/s00439-015-1627-5. Epub 2015 Dec 29.
הצטרפו לשיחה
שתפו את מחשבותיכם או חוויותיכם עם אחרים ב קהילות המטופלים שלנו.
שאלו, שתפו, התחברו.
עיין בדיונים, שאל שאלות ושתף חוויות במאות נושאים בריאותיים.
הירשמו לניוזלטר של פיישנט
המנה השבועית שלך של עצות בריאות ברורות ואמינות - נכתבה כדי לעזור לך להרגיש מעודכן, בטוח ובשליטה.
על ידי הרשמה אתה מקבל את שלנו מדיניות הפרטיות שלנו. באפשרותך לבטל את המנוי בכל עת. לעולם לא נמכור את הנתונים שלך.