snail family transcriptional repressor 2
עודכן לאחרונה 17 אוג 2022
עומד בהנחיות העריכה של Patient
- הורדהורד
- שתף
- Language
- דיון
- גרסת שמע
- הוסף למקורות מועדפים בגוגל
ה SNAI2 gene (often called SLUG) provides the instructions for making a protein called snail 2. Snail 2 belongs to the snail protein family, which plays a role in the formation of tissues during embryonic development. The snail 2 protein is also found in most adult tissues, so it probably helps maintain the normal function of cells after birth. To carry out these roles, snail 2 attaches to critical regions of DNA and helps control the activity of particular genes. On the basis of this action, the protein is called a transcription factor.
Normal function
ה SNAI2 gene (often called SLUG) provides the instructions for making a protein called snail 2. Snail 2 belongs to the snail protein family, which plays a role in the formation of tissues during embryonic development. The snail 2 protein is also found in most adult tissues, so it probably helps maintain the normal function of cells after birth. To carry out these roles, snail 2 attaches to critical regions of DNA and helps control the activity of particular genes. On the basis of this action, the protein is called a transcription factor.
Research indicates that the snail 2 protein is required during embryonic growth for the development of cells called neural crest cells. Neural crest cells migrate from the developing spinal cord to specific regions in the embryo and give rise to many tissues and cell types, including some nerve tissue and pigment-producing cells called melanocytes. Melanocytes produce the pigment melanin, which contributes to hair, eye, and skin colour. Melanocytes are also found in certain regions of the brain and inner ear. The snail 2 protein probably plays a role in the formation and survival of melanocytes.
Conditions referring to this gene or chromosome
Other names
neural crest transcription factor SLUG
SLUG
slug homolog, zinc finger protein (chicken)
SLUG_HUMAN
SLUGH1
snail 2
snail family zinc finger 2
snail homolog 2 (Drosophila)
SNAIL2
WS2D
Related patient information and medicines
Patient information leaflet
נסיעה למקומות מרוחקים
איזה preparation and advance planning are required for remote travel. Time spent in understanding your destination and preparing for the conditions you can expect will help ensure you ... Self-treatment is a last resort as it is very difficult for anyone to make treatment decisions about themselves. Reference book Pocket First Aid and Wilderness.
Patient information leaflet
תולעים עגולות
Roundworms (also called nematodes) are worms with a long round body. They vary in length from several millimetres to up to two metres. Soil and water supplies may become contaminated with roundworm eggs in areas of poor sanitation. Many roundworms have a complicated life cycle that includes both main hosts (large mammals such as humans or pigs).
Patient information leaflet
בילרציה
How do you get schistosomiasis. בילרציה is a tropical disease caused by a parasitic infection with worms from the Schistosomatidae family. A parasite is an animal that lives on or in another animal and feeds from it. There are three main worm species that cause schistos... How common is schistosomiasis. The World Health Organization (WHO).
Patient information leaflet
טינטון
For example: Tinnitus often develops at the same time as the heari... Ménière's disease. In this condition you develop attacks of dizziness (vertigo), hearing loss and tinnitus. It is due to a problem of the cochlea - a snail-shaped chamber filled with fluid, in the inner ear. Exposure to very loud noise. Some people develop persistent tinnitus.
Patient information leaflet
האם אני יכול לקחת אזיתרומיצין וטרבוטלין יחד?
Taking azithromycin and terbutaline together may increase the risk of developing an irregular heart rhythm. Using othe... Our בודק אינטראקציות בין תרופות helps you check whether your prescriptions, over-the-counter medicines, ו תוספים are safe to take together. Simply search for your medicines to see potential interactions and what to do.
Patient information leaflet
האם אני יכול לקחת אספירין ונפרוקסן יחד?
Why this happens Both סמים belong to the same family (NSAIDs) and work by blocking enzymes called COX-1 and COX-2. Our בודק אינטראקציות בין תרופות helps you check whether your prescriptions, over-the-counter medicines, ו תוספים are safe to take together. הבהרה This information is for general educational purposes only and should not.
קריאה נוספת והפניות
- snail family transcriptional repressor 2; MedlinePlus, National Library of Medicine.
- Cohen ME, Yin M, Paznekas WA, Schertzer M, Wood S, Jabs EW. Human SLUG gene organization, expression, and chromosome map location on 8q. Genomics. 1998 Aug 1;51(3):468-71. doi: 10.1006/geno.1998.5367.
- Dessinioti C, Stratigos AJ, Rigopoulos D, Katsambas AD. A review of genetic disorders of hypopigmentation: lessons learned from the biology of melanocytes. Exp Dermatol. 2009 Sep;18(9):741-9. doi: 10.1111/j.1600-0625.2009.00896.x. Epub 2009 Jun 23.
- Hemavathy K, Guru SC, Harris J, Chen JD, Ip YT. Human Slug is a repressor that localizes to sites of active transcription. Mol Cell Biol. 2000 Jul;20(14):5087-95. doi: 10.1128/MCB.20.14.5087-5095.2000.
- Lopez V, Jorda E. Piebaldism in a 2-year-old girl. Dermatol Online J. 2011 Feb 15;17(2):13.
- Sanchez-Martin M, Perez-Losada J, Rodriguez-Garcia A, Gonzalez-Sanchez B, Korf BR, Kuster W, Moss C, Spritz RA, Sanchez-Garcia I. Deletion of the SLUG (SNAI2) gene results in human piebaldism. Am J Med Genet A. 2003 Oct 1;122A(2):125-32. doi: 10.1002/ajmg.a.20345.
- Sanchez-Martin M, Rodriguez-Garcia A, Perez-Losada J, Sagrera A, Read AP, Sanchez-Garcia I. SLUG (SNAI2) deletions in patients with Waardenburg disease. Hum Mol Genet. 2002 Dec 1;11(25):3231-6. doi: 10.1093/hmg/11.25.3231.
הצטרפו לשיחה
שתפו את מחשבותיכם או חוויותיכם עם אחרים ב קהילות המטופלים שלנו.
שאלו, שתפו, התחברו.
עיין בדיונים, שאל שאלות ושתף חוויות במאות נושאים בריאותיים.
הירשמו לניוזלטר של פיישנט
המנה השבועית שלך של עצות בריאות ברורות ואמינות - נכתבה כדי לעזור לך להרגיש מעודכן, בטוח ובשליטה.
על ידי הרשמה אתה מקבל את שלנו מדיניות הפרטיות שלנו. באפשרותך לבטל את המנוי בכל עת. לעולם לא נמכור את הנתונים שלך.