דלג לתוכן הראשי

three prime repair exonuclease 1

The TREX1 gene provides instructions for making the three prime repair exonuclease 1 enzyme. This enzyme is a DNA exonuclease, which means that it trims molecules of DNA by removing DNA building blocks (nucleotides) from the ends.

Normal function

The TREX1 gene provides instructions for making the three prime repair exonuclease 1 enzyme. This enzyme is a DNA exonuclease, which means that it trims molecules of DNA by removing DNA building blocks (nucleotides) from the ends.

The three prime repair exonuclease 1 enzyme is helps remove incorrect or damaged nucleotides from DNA. These DNA fragments are created during cell division, DNA repair, cell death (apoptosis), and other processes. The removal of these nucleotides creates even DNA ends, which are necessary for maintaining the stability of genetic material.

Unusual pieces of DNA may be mistaken by cells for the genetic material of viral invaders, triggering immune system reactions. The three prime repair exonuclease 1 enzyme removes pieces of DNA that might otherwise set off an immune response.

Conditions referring to this gene or chromosome

Other names

3' repair exonuclease 1

3'-5' exonuclease TREX1

deoxyribonuclease III, dnaQ/mutD-like

DNase III

DRN3

TREX1_HUMAN

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