Rilpivirine tablets for HIV

About rilpivirine

Rilpivirine is an antiretroviral medicine. It is used for human immunodeficiency virus (HIV) infection. It slows the progress of HIV infection, but it is not a cure. HIV destroys cells in the body, called CD4 T cells. These cells are a type of white blood cell and are important because they are involved in protecting your body from infection. If left untreated, the HIV infection weakens your immune system so that your body cannot defend itself against bacteria, viruses and other germs. Rilpivirine slows down the progress of HIV infection by reducing the amount of virus in your body. It does this by stopping the virus from copying (replicating) itself.

Rilpivirine will be prescribed for you by a doctor who is a specialist. It belongs to a group of antiretroviral medicines known as non-nucleoside reverse transcriptase inhibitors (NNRTIs). It is given alongside a number of other antiretroviral medicines, as part of a combination therapy. Taking three or more antiretroviral medicines at the same time is more effective than taking one alone. Taking a combination of different medicines also reduces the risk that the virus will become resistant to any individual medicine. It is vital to take them exactly as prescribed to maintain success and to help to prevent the virus from becoming resistant to the medicines. These medicines are usually taken for life.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking rilpivirine it is important that your doctor knows:

• אם את בהריון, מנסה להיכנס להריון או מניקה.

• אם יש לך בעיות בתפקוד הכבד שלך, או אם יש לך בעיות בתפקוד הכליות שלך.

• אם אתה נוטל תרופות אחרות כלשהן. זה כולל כל תרופה שניתן לרכוש ללא מרשם, כמו גם תרופות צמחיות ומשלימות.

• אם אי פעם הייתה לך תגובה אלרגית לתרופה.

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about rilpivirine, and it will also provide you with a full list of the side-effects which you could experience from taking it.

• Take rilpivirine exactly as your doctor tells you to. The usual dose is one 25 mg tablet daily. It is important that you take the tablets with a meal, as this will help your body to absorb the full dose. Please note - it is not sufficient to take the tablet with a protein-rich nutritional drink instead of a meal.

• Swallow the tablets whole with a drink of water. Do not crush, break or chew the tablets.

• Try to take your doses at the same time of day each day, as this will help you to remember to take rilpivirine regularly.

• If you forget to take a tablet at your usual time, you should take it (with a meal) as soon as you remember, providing it is within 12 hours of the time you should have taken the dose. If when you remember, it is more than 12 hours late then do not take the missed tablet, but do remember to take your next tablet on time. Do not take two doses together to make up for a missed dose.

• Keep your regular appointments with your doctor so that your progress can be monitored. You will need to have regular blood tests.

• It is important that you continue to take rilpivirine and your other antiretroviral treatment regularly. This will help to prevent the HIV from becoming resistant to the medicines you are taking. Even if you miss only a small number of doses, the virus can become resistant to treatment.

• If you develop an infection soon after you start the treatment, let your doctor know. As a result of taking rilpivirine, your immune system may start fighting an infection which was present before you started the treatment, but which you may not have been aware of.

• Follow carefully any advice your doctor gives to you about making lifestyle changes to reduce any risk of damage to your heart and blood vessels. These can include stopping smoking, eating healthily and taking regular exercise.

• Although treatment with antiretroviral medicines may reduce the risk of you passing HIV to others through sexual contact, it does not stop it. It is important that you use condoms.

• If you are trying for a baby or become pregnant whilst taking rilpivirine, let your doctor know straightaway. Rilpivirine may become less effective during pregnancy and your doctor might ask you to take a different medicine.

• It is not uncommon for people with HIV to feel low or even depressed, especially soon after the diagnosis has been made and treatment has been started. If you have any feelings of depression, or any distressing thoughts about harming yourself, then you should speak with your doctor straightaway.

• Some people who have taken antiretroviral medicines (particularly over a long time) have developed a condition called osteonecrosis. This is a bone disease where bone tissue dies because there is a reduced blood supply to it. It leads to joint pains and stiffness, and can cause difficulties in movement. If you notice any of these symptoms, speak with your doctor.

• If you buy any medicines, supplements or herbal remedies 'over the counter', check with a pharmacist that they are suitable to take with rilpivirine and your other medicines. This is because some medicines interfere with antiretrovirals and can stop them from working properly. In particular, do not take St John's wort. Also, some antacids can reduce the amount of rilpivirine your body absorbs. Because of this, it is recommended that you do not take indigestion remedies during the two hours before or during the four hours after you take rilpivirine.

• Some people taking antiretroviral medicines develop changes to the way body fat is distributed in the body. This can result in changes to body image. Your doctor will discuss the possibility of this with you.

• אם אתה עובר ניתוח או טיפול שיניים, אמור לאדם שמבצע את הטיפול אילו תרופות אתה נוטל.

• Treatment for HIV is usually lifelong. Continue to take rilpivirine regularly, even if you feel well. This is to keep your immune system healthy.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with rilpivirine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

אם אתה חווה תסמינים נוספים שלדעתך עשויים להיות כתוצאה מהטבליות, פנה לרופא או לרוקח שלך לקבלת ייעוץ נוסף.

• שמור את כל התרופות מחוץ להישג ידם וראייתם של ילדים.

• יש לאחסן במקום קריר ויבש, הרחק מחום ואור ישיר.