ADAMTS like 2
עודכן לאחרונה 25 בפברואר 2026
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The ADAMTSL2 gene provides instructions for making a protein whose exact function is unknown. The ADAMTSL2 protein is active in many different tissues and is found in the extracellular matrix, which is the intricate lattice of proteins and other molecules that forms in the spaces between cells.
Normal function
The ADAMTSL2 gene provides instructions for making a protein whose exact function is unknown. The ADAMTSL2 protein is active in many different tissues and is found in the extracellular matrix, which is the intricate lattice of proteins and other molecules that forms in the spaces between cells.
Studies suggest that the ADAMTSL2 protein interacts with a protein called latent transforming growth factor beta-binding protein 1 (LTBP1). The LTBP1 protein is involved in the storage of another protein called transforming growth factor beta (TGF-β). TGF-β helps regulate important cell processes, including the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement, and the self-destruction of cells (apoptosis).
The interaction between the ADAMTSL2 and LTBP1 proteins suggests that ADAMTSL2 may play a role in the microfibrillar network. This organized arrangement of thread-like filaments (microfibrils) within the extracellular matrix provides strength and flexibility to tissues throughout the body.
Researchers also suspect that the ADAMTSL2 protein may help regulate the availability of TGF-β, which is stored in the microfibrillar network. Once released from the microfibrillar network, TGF-β activates important signaling pathways, including the signaling pathways involved in bone formation.
Conditions referring to this gene or chromosome
Other names
KIAA0605
Related patient information and medicines
Patient information leaflet
האם אני יכול לקחת פקסופנדין ולוסרטן יחד?
There are no known significant interactions between fexofenadine and losartan. Losartan is a blood pressure medication processed by specific liver enzymes (CYP2C9 and CYP3A4). Because they use different pathways in the body and do not affec... Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions.
Patient information leaflet
תזונה לסוכרת סוג 2
The first-line treatment for סוכרת סוג 2 involves making changes to your lifestyle, through diet, weight control and physical activity. Regular check-ups and medication for diabetes (whether in tablet or injection form) definitely aren't the only way to control your blood sugar (glucose) levels. In fact, there is evidence that many people who.
Patient information leaflet
האם אני יכול לקחת אפיקסבן ותוספי סיבים יחד?
It is best to stick to moderate drinking limits. Using other medicines Taking multiple medicines. Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them. Disclaimer.
Patient information leaflet
סוכרת סוג 2
סוכרת סוג 2 can occur at any age, including during childhood, but it occurs mainly in people aged over 40. The first-line treatment is diet, weight control and physical activity. Other treatments include reducing blood pressure if it is high, lowering high cholesterol levels, and also other me... This is called insulin resistance. You can.
Patient information leaflet
טיפול בסוכרת סוג 2
Although סוכרת cannot be cured, it can be treated successfully. If a high blood sugar level is brought down to a normal level, your symptoms will ease and your risk of long-term complications will be much lower. Managing type 2 diabetes Keeping your blood sugar (glucose) well controlled is key to reducing your risk of long-term complications.
Patient information leaflet
האם אני יכול לקחת גלוקומנן ונקספלנון יחד?
Glucomannan is a type of fibre that can slow down or reduce how much of your contraceptive medication is absorbed into your bloodstream. This could potentially make the Nexplanon implant less effective at preventing pregnancy. Why this happens Glucomannan is a highly absorbent fibre that forms a thick gel in the stomach and intestines. This gel.
קריאה נוספת והפניות
- ADAMTS like 2; MedlinePlus, National Library of Medicine.
- Camarena V, Williams MM, Morales AA, Zafeer MF, Kilic OV, Kamiar A, Abad C, Rasmussen MA, Briski LM, Peart L, Bademci G, Barbouth DS, Smithson S, Wang G, Shehadeh LA, Walz K, Tekin M. ADAMTSL2 mutations determine the phenotypic severity in geleophysic dysplasia. JCI Insight. 2024 Feb 1;9(5):e174417. doi: 10.1172/jci.insight.174417.
- Le Goff C, Morice-Picard F, Dagoneau N, Wang LW, Perrot C, Crow YJ, Bauer F, Flori E, Prost-Squarcioni C, Krakow D, Ge G, Greenspan DS, Bonnet D, Le Merrer M, Munnich A, Apte SS, Cormier-Daire V. ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation. Nat Genet. 2008 Sep;40(9):1119-23. doi: 10.1038/ng.199.
- Marzin P, Cormier-Daire V. Geleophysic Dysplasia. 2009 Sep 22 [updated 2024 Mar 28]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK11168/
- Piccolo P, Sabatino V, Mithbaokar P, Polishchuck E, Law SK, Magraner-Pardo L, Pons T, Polishchuck R, Brunetti-Pierri N. Geleophysic dysplasia: novel missense variants and insights into ADAMTSL2 intracellular trafficking. Mol Genet Metab Rep. 2019 Sep 5;21:100504. doi: 10.1016/j.ymgmr.2019.100504. eCollection 2019 Dec.
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