FA complementation group C
עודכן לאחרונה 3 במרץ 2025
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The FANCC gene provides instructions for making a protein that is involved in a process known as the Fanconi anaemia (FA) pathway. The FA pathway turns on (activates) when the process of making new copies of DNA, called DNA replication, is blocked due to DNA damage. The FA pathway prevents a certain type of DNA damage known as interstrand cross-links (ICLs). ICLs are abnormal connections between two DNA building blocks (nucleotides) on opposite strands of DNA. These cross-links stop the process of DNA replication and can be caused by a buildup of toxic substances produced in the body or by treatment with certain cancer therapy drugs (sometimes known as DNA cross-linking agents).
Normal function
The FANCC gene provides instructions for making a protein that is involved in a process known as the Fanconi anaemia (FA) pathway. The FA pathway turns on (activates) when the process of making new copies of DNA, called DNA replication, is blocked due to DNA damage. The FA pathway prevents a certain type of DNA damage known as interstrand cross-links (ICLs). ICLs are abnormal connections between two DNA building blocks (nucleotides) on opposite strands of DNA. These cross-links stop the process of DNA replication and can be caused by a buildup of toxic substances produced in the body or by treatment with certain cancer therapy drugs (sometimes known as DNA cross-linking agents).
The FANCC protein is one of several proteins that form a group known as the FA core complex. The FA core complex is composed of eight FA proteins (including FANCC) and two proteins called Fanconi anaemia-associated proteins (FAAPs). This complex activates two proteins, called FANCD2 and FANCI, by attaching a single molecule called ubiquitin to each of them (a process called monoubiquitination). The activation of FANCD2 and FANCI attracts DNA repair proteins to the damaged area of DNA so the cross-link can be removed and DNA replication can continue.
Conditions referring to this gene or chromosome
Other names
FACC
FANCC_HUMAN
Fanconi anaemia, complementation group C
Related patient information and medicines
Patient information leaflet
זיהום מנינגוקוקלי
Neisseria meningitidis , also known as meningococcus, is a germ (bacterium). Types of meningococcal infection Meningococcal germs (bacteria) are divided into several groups (types or strains): Groups B, C and, more recently, W are the common strains in the UK. Most of the rest are caused by group C (although the number of group C cases has fallen.
Patient information leaflet
חיסון מנינגוקוקלי לדלקת קרום המוח
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Patient information leaflet
בדיקות דם
ה main reasons to know your blood group are if you צורך to have a blood transfusion or if you are pregnant. You cannot request a blood test just to know your blood group on the NHS. What is blood made up of. Blood cells These can be seen under a microscope and make up about 40% of the blood's volume. Blood cells are made in the bone marrow by.
Patient information leaflet
דלקת קרום המוח
These include Haemophilus influenzae type ב (Hib), group B and C meningococcus, pneumococcus and mumps. ה חיסון for Group B meningococcus became part of the normal UK immunisation schedule מ September 2015. A vaccine protecting against types A, C, W and Y מטופל? available for those aged 17-18 years and those ב their first year at university..
Patient information leaflet
התעלפות
Fainting is a temporary loss of consciousness that happens when the brain does not receive enough oxygen בגלל of reduced blood flow to the brain. Driving and faints The Driver and Vehicle Licensing Agency (DVLA) rules on dr... For Group 1 (car and motorcycle) license holders, 'simple' faints (vasovagal syncope) that occur only whilst standing.
Patient information leaflet
סוגי דם וקבוצות
ABO and rhesus are both types of antigens found on the surface of red blood cells. There are lots of other types but these are the most important. The main reasons to know your blood group are if you need to have a blood transfusion or if you are pregnant. What is a blood group. Red blood cells (erythrocytes) have certain proteins on their.
קריאה נוספת והפניות
- FA complementation group C; MedlinePlus, National Library of Medicine.
- de Winter JP, Joenje H. The genetic and molecular basis of Fanconi anemia. Mutat Res. 2009 Jul 31;668(1-2):11-9. doi: 10.1016/j.mrfmmm.2008.11.004. Epub 2008 Nov 14.
- Deakyne JS, Mazin AV. Fanconi anemia: at the crossroads of DNA repair. Biochemistry (Mosc). 2011 Jan;76(1):36-48. doi: 10.1134/s0006297911010068.
- Kee Y, D'Andrea AD. Expanded roles of the Fanconi anemia pathway in preserving genomic stability. Genes Dev. 2010 Aug 15;24(16):1680-94. doi: 10.1101/gad.1955310.
- Kitao H, Takata M. Fanconi anemia: a disorder defective in the DNA damage response. Int J Hematol. 2011 Apr;93(4):417-424. doi: 10.1007/s12185-011-0777-z. Epub 2011 Feb 18.
- Mathew CG. Fanconi anaemia genes and susceptibility to cancer. Oncogene. 2006 Sep 25;25(43):5875-84. doi: 10.1038/sj.onc.1209878.
- Mehta PA, Ebens CL. Fanconi Anemia. 2002 Feb 14 [updated 2026 Jan 15]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK1401/
- Taniguchi T, D'Andrea AD. Molecular pathogenesis of Fanconi anemia: recent progress. Blood. 2006 Jun 1;107(11):4223-33. doi: 10.1182/blood-2005-10-4240. Epub 2006 Feb 21.
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