LDL receptor related protein 5
עודכן לאחרונה 26 Sept 2025
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The LRP5 gene provides instructions for making a protein that is embedded in the outer membrane of many types of cells. This protein is known as a co-receptor because it works with another receptor protein, frizzled-4 (produced from the FZD4 gene), to transmit chemical signals from outside the cell to the cell's nucleus. Frizzled-4 and the LRP5 protein participate in the Wnt signaling pathway, a series of steps that affect the way cells and tissues develop. Wnt signaling is important for cell division (proliferation), attachment of cells to one another (adhesion), cell movement (migration), and many other cellular activities.
Normal function
The LRP5 gene provides instructions for making a protein that is embedded in the outer membrane of many types of cells. This protein is known as a co-receptor because it works with another receptor protein, frizzled-4 (produced from the FZD4 gene), to transmit chemical signals from outside the cell to the cell's nucleus. Frizzled-4 and the LRP5 protein participate in the Wnt signaling pathway, a series of steps that affect the way cells and tissues develop. Wnt signaling is important for cell division (proliferation), attachment of cells to one another (adhesion), cell movement (migration), and many other cellular activities.
The LRP5 protein plays an important role in the development and maintenance of several tissues. During early development, it helps guide the specialization of cells in the retina, which is the light-sensitive tissue that lines the back of the eye. The LRP5 protein is also involved in forming blood vessels in the retina and in the inner ear. Additionally, this protein helps regulate bone mineral density, which is a measure of the amount of calcium and other minerals in bones. The minerals give the bones strength, making them less likely to break.
Conditions referring to this gene or chromosome
Other names
BMND1
EVR1
EVR4
HBM
low density lipoprotein receptor-related protein 5
low density lipoprotein receptor-related protein 7
LR3
LRP5_HUMAN
LRP7
OPS
OPTA1
VBCH2
Related patient information and medicines
Patient information leaflet
היפרכולסטרולמיה משפחתית
Familial ... There are three main genes that can be involved in FH: LDL receptor genes: this is the most common faulty gene in FH. It means there aren't enough LDL receptors, so cholesterol builds up in the blood. APOB gene (apolipoprotein B): a fault with this gene means כולסטרול LDL can’t bind well to LDL receptors so that blood levels of LDL.
Patient information leaflet
מחלת כליות כרונית
This is because they can prevent further worsening of the kidney function. These medicines are called: Angiotensin-converting enzyme (ACE) inhibitors (for example, captopril, enalapril, ramipril, lisinopril); and Angiotensin receptor blockers (ARBs), such as losartan, valsartan, candesartan, telmisartan). SGLT2 inhibitors. A group of medicines.
Patient information leaflet
כולסטרול גבוה
כולסטרול is a fat chemical (lipid) that is made in the cells in your body. Many different cells make cholesterol but cells in the liver make about a quarter of the total. You need some cholesterol to keep healthy. What is high cholesterol. High cholesterol refers to elevated levels of cholesterol in the blood. If your cholesterol levels are.
Patient information leaflet
תסמונת נפרוטית
Nephrotic syndrome is a condition where the 'filters' in the kidney become 'leaky' and large amounts of חלבון leak from the blood into the urine. The main symptom is fluid retention (oedema) which is mainly due to the low protein level in the blood. Various diseases can cause nephrotic syndrome, some more serious than others. Treatment and.
Patient information leaflet
מחלת כליות סוכרתית
מהו diabetic kidney disease. Diabetic kidney disease (diabetic nephropathy) is a complication that occurs in some people with diabetes. Diabetic kidney disease is one of the causes of chronic kidney disease , a long-term condition where the kidneys do not work as well as they should. In diabetic kidney disease, the filters of the kidneys, the.
Patient information leaflet
חוסמי בטא
חוסמי בטא are medicines that are used to treat a variety of conditions. Their full correct name is beta-adrenoceptor blocking medicines (or beta-adrenergic blocking agents), but they are commonly just called beta-blockers. How do beta-blockers work. Beta-blockers work by blocking the transmission of certain nerve impulses. The ends of some.
קריאה נוספת והפניות
- LDL receptor related protein 5; MedlinePlus, National Library of Medicine.
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- Gong Y, Slee RB, Fukai N, Rawadi G, Roman-Roman S, Reginato AM, Wang H, Cundy T, Glorieux FH, Lev D, Zacharin M, Oexle K, Marcelino J, Suwairi W, Heeger S, Sabatakos G, Apte S, Adkins WN, Allgrove J, Arslan-Kirchner M, Batch JA, Beighton P, Black GC, Boles RG, Boon LM, Borrone C, Brunner HG, Carle GF, Dallapiccola B, De Paepe A, Floege B, Halfhide ML, Hall B, Hennekam RC, Hirose T, Jans A, Juppner H, Kim CA, Keppler-Noreuil K, Kohlschuetter A, LaCombe D, Lambert M, Lemyre E, Letteboer T, Peltonen L, Ramesar RS, Romanengo M, Somer H, Steichen-Gersdorf E, Steinmann B, Sullivan B, Superti-Furga A, Swoboda W, van den Boogaard MJ, Van Hul W, Vikkula M, Votruba M, Zabel B, Garcia T, Baron R, Olsen BR, Warman ML; Osteoporosis-Pseudoglioma Syndrome Collaborative Group. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell. 2001 Nov 16;107(4):513-23. doi: 10.1016/s0092-8674(01)00571-2.
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