transforming growth factor beta 1
עודכן לאחרונה 2 May 2023
עומד בהנחיות העריכה של Patient
- הורדהורד
- שתף
- Language
- דיון
- גרסת שמע
- הוסף למקורות מועדפים בגוגל
ה TGFB1 gene provides instructions for producing a protein called transforming growth factor beta-1 (TGFβ-1). The TGFβ-1 protein triggers chemical signals that regulate various cell activities inside the cell, including the growth and division (proliferation) of cells, the maturation of cells to carry out specific functions (differentiation), cell movement (motility), and controlled cell death (apoptosis).
Normal function
ה TGFB1 gene provides instructions for producing a protein called transforming growth factor beta-1 (TGFβ-1). The TGFβ-1 protein triggers chemical signals that regulate various cell activities inside the cell, including the growth and division (proliferation) of cells, the maturation of cells to carry out specific functions (differentiation), cell movement (motility), and controlled cell death (apoptosis).
The TGFβ-1 protein is found throughout the body but is particularly abundant in tissues that make up the skeleton, where it helps regulate the formation and growth of bone and cartilage, a tough, flexible tissue that makes up much of the skeleton during early development. TGFβ-1 is also involved in the formation of blood vessels, development of muscle tissue and body fat, wound healing, inflammatory processes in the immune system, and prevention of tumour growth.
Conditions referring to this gene or chromosome
Other names
TGF-beta 1 protein
TGF-beta-1
TGFB
TGFB1_HUMAN
TGFbeta
transforming growth factor, beta 1
Related patient information and medicines
Patient information leaflet
אקרומגליה
אקרומגליה is a rare, progressive condition in which you make too much growth hormone. This causes a range of symptoms that develop gradually, often over several years. This is because growth hormone stimulates the growth of bones, and in children, bones are still in their growing phase until the... Note : the rest of this leaflet is about.
Patient information leaflet
תלסמיה
Thalassaemia is an inherited condition affecting the blood. Thalassaemia is an inherited (genetic) condition affecting the blood. Haemoglobin is made out of different parts. The main parts are called alpha chains and beta chains which are put together to make the haemoglobin molecule. In thalassaemia, part of the haemoglobin is faulty - usually.
Patient information leaflet
חוסר בוויטמין A
Vitamin ... Foods that contain vitamin A include liver, milk, eggs and fish-liver oils. Another substance called beta carotene (which is found in green leafy and orange/yellow vegetables and fruits) can also be converted by your body to vitamin A. Mild forms of vitamin A deficiency can usually be treated without any long-term problems. Vitamin A.
Patient information leaflet
התקף לב
ה התקף לב (אוטם שריר הלב) is usually caused by a blood clot, which stops the blood flowing to a part of your לב muscle. You should call for an ambulance immediately if you develop severe chest pain. If someone has a heart attack, treatment with a clot-busting medicine or an emergency procedure to restore the blood flow through the.
Patient information leaflet
טלוגן אפלוביום
Telogen effluvium (hair loss) מטופל? a condition where more than normal amounts of hair fall out. There is a general 'thinning' of the hair. Unlike some other hair and scalp conditions, it is temporary and the hair growth usually recovers. What is telogen effluvium. Telogen effluvium is rapid hair loss that is caused by stress or a change to your.
Patient information leaflet
רטינופתיה של פגות
Retinopathy of prematurity is an eye condition which can develop in premature babies. It can cause loss of vision or visual impairment if not treated. However, this can usua... What is retinopathy of prematurity. Retinopathy of prematurity (ROP) is an eye problem which can occur ב babies ש were born too early ( premature babies ). It.
קריאה נוספת והפניות
- transforming growth factor beta 1; MedlinePlus, National Library of Medicine.
- Eurekah Bioscience Collection: Transforming Growth Factor-β
- Fujio K, Komai T, Inoue M, Morita K, Okamura T, Yamamoto K. Revisiting the regulatory roles of the TGF-beta family of cytokines. Autoimmun Rev. 2016 Sep;15(9):917-22. doi: 10.1016/j.autrev.2016.07.007. Epub 2016 Jul 5.
- Janssens K, ten Dijke P, Ralston SH, Bergmann C, Van Hul W. Transforming growth factor-beta 1 mutations in Camurati-Engelmann disease lead to increased signaling by altering either activation or secretion of the mutant protein. J Biol Chem. 2003 Feb 28;278(9):7718-24. doi: 10.1074/jbc.M208857200. Epub 2002 Dec 18.
- Janssens K, Vanhoenacker F, Bonduelle M, Verbruggen L, Van Maldergem L, Ralston S, Guanabens N, Migone N, Wientroub S, Divizia MT, Bergmann C, Bennett C, Simsek S, Melancon S, Cundy T, Van Hul W. Camurati-Engelmann disease: review of the clinical, radiological, and molecular data of 24 families and implications for diagnosis and treatment. J Med Genet. 2006 Jan;43(1):1-11. doi: 10.1136/jmg.2005.033522. Epub 2005 May 13.
- Long J, Liu Z, Wu X, Xu Y, Ge C. Gene expression profile analysis of pancreatic cancer based on microarray data. Mol Med Rep. 2016 May;13(5):3913-9. doi: 10.3892/mmr.2016.5021. Epub 2016 Mar 21.
- Ma X, Chen C, Xiong H, Li Y. Transforming growth factorbeta1 L10P variant plays an active role on the breast cancer susceptibility in Caucasian: evidence from 10,392 cases and 11,697 controls. Breast Cancer Res Treat. 2010 Nov;124(2):453-7. doi: 10.1007/s10549-010-0843-x. Epub 2010 Mar 27.
- Poniatowski LA, Wojdasiewicz P, Gasik R, Szukiewicz D. Transforming growth factor Beta family: insight into the role of growth factors in regulation of fracture healing biology and potential clinical applications. Mediators Inflamm. 2015;2015:137823. doi: 10.1155/2015/137823. Epub 2015 Jan 29.
- Wallace SE, Lachman RS, Mekikian PB, Bui KK, Wilcox WR. Marked phenotypic variability in progressive diaphyseal dysplasia (Camurati-Engelmann disease): report of a four-generation pedigree, identification of a mutation in TGFB1, and review. Am J Med Genet A. 2004 Sep 1;129A(3):235-47. doi: 10.1002/ajmg.a.30148.
- Walton KL, Makanji Y, Chen J, Wilce MC, Chan KL, Robertson DM, Harrison CA. Two distinct regions of latency-associated peptide coordinate stability of the latent transforming growth factor-beta1 complex. J Biol Chem. 2010 May 28;285(22):17029-37. doi: 10.1074/jbc.M110.110288. Epub 2010 Mar 22.
- Zhao L, Hantash BM. TGF-beta1 regulates differentiation of bone marrow mesenchymal stem cells. Vitam Horm. 2011;87:127-41. doi: 10.1016/B978-0-12-386015-6.00042-1.
הצטרפו לשיחה
שתפו את מחשבותיכם או חוויותיכם עם אחרים ב קהילות המטופלים שלנו.
שאלו, שתפו, התחברו.
עיין בדיונים, שאל שאלות ושתף חוויות במאות נושאים בריאותיים.
הירשמו לניוזלטר של פיישנט
המנה השבועית שלך של עצות בריאות ברורות ואמינות - נכתבה כדי לעזור לך להרגיש מעודכן, בטוח ובשליטה.
על ידי הרשמה אתה מקבל את שלנו מדיניות הפרטיות שלנו. באפשרותך לבטל את המנוי בכל עת. לעולם לא נמכור את הנתונים שלך.