zinc finger protein 341
עודכן לאחרונה 18 Aug 2020
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ה ZNF341 gene provides instructions for making a transcription factor, which is a protein that attaches (binds) to specific regions of DNA and helps control the activity of particular genes. The ZNF341 protein is thought to regulate the activity of the STAT1 ו STAT3 genes, controlling production of the STAT1 and STAT3 proteins, respectively. Both proteins are involved in the immune system. They control pathways in cells that help fight foreign invaders such as viruses, bacteria, and fungi. The STAT3 protein, in particular, transmits signals for the maturation of immune system cells, especially T cells and B cells. STAT3 is also involved in normal development and maintenance of bones and other tissues.
Normal function
ה ZNF341 gene provides instructions for making a transcription factor, which is a protein that attaches (binds) to specific regions of DNA and helps control the activity of particular genes. The ZNF341 protein is thought to regulate the activity of the STAT1 ו STAT3 genes, controlling production of the STAT1 and STAT3 proteins, respectively. Both proteins are involved in the immune system. They control pathways in cells that help fight foreign invaders such as viruses, bacteria, and fungi. The STAT3 protein, in particular, transmits signals for the maturation of immune system cells, especially T cells and B cells. STAT3 is also involved in normal development and maintenance of bones and other tissues.
Researchers suspect that the ZNF341 protein controls the activity of other genes, although they have not been identified.
Conditions referring to this gene or chromosome
Other names
ZNF341 gene
Related patient information and medicines
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מחלת וילסון
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שחמת
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טלוגן אפלוביום
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שיעול והצטננות אצל ילדים
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עדשות מגע
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גמילה בהובלת התינוק
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קריאה נוספת והפניות
- zinc finger protein 341; MedlinePlus, National Library of Medicine.
- Beziat V, Li J, Lin JX, Ma CS, Li P, Bousfiha A, Pellier I, Zoghi S, Baris S, Keles S, Gray P, Du N, Wang Y, Zerbib Y, Levy R, Leclercq T, About F, Lim AI, Rao G, Payne K, Pelham SJ, Avery DT, Deenick EK, Pillay B, Chou J, Guery R, Belkadi A, Guerin A, Migaud M, Rattina V, Ailal F, Benhsaien I, Bouaziz M, Habib T, Chaussabel D, Marr N, El-Benna J, Grimbacher B, Wargon O, Bustamante J, Boisson B, Muller-Fleckenstein I, Fleckenstein B, Chandesris MO, Titeux M, Fraitag S, Alyanakian MA, Leruez-Ville M, Picard C, Meyts I, Di Santo JP, Hovnanian A, Somer A, Ozen A, Rezaei N, Chatila TA, Abel L, Leonard WJ, Tangye SG, Puel A, Casanova JL. A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity. Sci Immunol. 2018 Jun 15;3(24):eaat4956. doi: 10.1126/sciimmunol.aat4956.
- Frey-Jakobs S, Hartberger JM, Fliegauf M, Bossen C, Wehmeyer ML, Neubauer JC, Bulashevska A, Proietti M, Frobel P, Noltner C, Yang L, Rojas-Restrepo J, Langer N, Winzer S, Engelhardt KR, Glocker C, Pfeifer D, Klein A, Schaffer AA, Lagovsky I, Lachover-Roth I, Beziat V, Puel A, Casanova JL, Fleckenstein B, Weidinger S, Kilic SS, Garty BZ, Etzioni A, Grimbacher B. ZNF341 controls STAT3 expression and thereby immunocompetence. Sci Immunol. 2018 Jun 15;3(24):eaat4941. doi: 10.1126/sciimmunol.aat4941.
- Zhang Q, Boisson B, Beziat V, Puel A, Casanova JL. Human hyper-IgE syndrome: singular or plural? Mamm Genome. 2018 Aug;29(7-8):603-617. doi: 10.1007/s00335-018-9767-2. Epub 2018 Aug 9.
הצטרפו לשיחה
שתפו את מחשבותיכם או חוויותיכם עם אחרים ב קהילות המטופלים שלנו.
שאלו, שתפו, התחברו.
עיין בדיונים, שאל שאלות ושתף חוויות במאות נושאים בריאותיים.
הירשמו לניוזלטר של פיישנט
המנה השבועית שלך של עצות בריאות ברורות ואמינות - נכתבה כדי לעזור לך להרגיש מעודכן, בטוח ובשליטה.
על ידי הרשמה אתה מקבל את שלנו מדיניות הפרטיות שלנו. באפשרותך לבטל את המנוי בכל עת. לעולם לא נמכור את הנתונים שלך.