Can I take Amlodipine and Bisoprolol together?

Why this happens

Both medicines work to lower blood pressure and slow the heart rate, but they do it in different ways. Amlodipine relaxes your blood vessels, while bisoprolol slows down the heart's contractions. When used together, their effects add up (an additive effect), which can sometimes lower your heart rate or blood pressure too much.

What you should do

It is common for doctors to prescribe these together, but you should be monitored closely. When you first start this combination or if your dose is increased, take extra care when standing up from a sitting or lying position. If you feel very dizzy, experience a slow pulse, or feel like you might faint, contact your doctor. Your doctor may want to check your blood pressure and heart rate regularly.

Important precautions

Asthma or Chronic Obstructive Pulmonary Disease (COPD)

Bisoprolol can cause narrowing of the airways, which may trigger a severe asthma attack or worsen breathing difficulties. It should generally be avoided if you have a history of asthma.

Diabetes

Bisoprolol can mask the warning signs of low blood sugar (hypoglycaemia), such as a fast heartbeat or tremors. You must monitor your blood sugar more closely.

Stopping treatment suddenly

Do not stop taking these medicines abruptly, especially bisoprolol. Doing so can cause a rapid rise in blood pressure or worsen chest pain (angina). Your dose must be reduced gradually under medical supervision.

Food and drink warnings

Grapefruit juice

Grapefruit juice can increase the amount of amlodipine in your blood, which may cause your blood pressure to drop too low and increase the risk of side effects like headaches or swollen ankles. Avoid drinking large amounts of grapefruit juice.

Alcohol

Alcohol can increase the blood-pressure-lowering effect of these medicines, which may make you feel dizzy, lightheaded, or sleepy, especially when you first start taking them or when your dose is increased. It is best to keep your alcohol intake within recommended limits and see how the medicine affects you.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.