Buserelin for men
Suprefact
נבדק על ידי Sid Dajaniעודכן לאחרונה על ידי Michael Stewart, MRPharmSLast updated 14 Sept 2024
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Buserelin (brand name Suprefact®) is a hormone treatment for men with prostate cancer who have not had surgery to remove the testicles.
Each time you collect your prescription for buserelin, check to make sure the brand name is Suprefact®. This is because there is another brand of buserelin nasal spray available, which is not suitable for you.
Use one spray into each nostril six times each day.
At a glance
Buserelin is a hormone treatment used to slow the growth of prostate cancer cells.
It reduces the male hormone testosterone, which prostate cancer cells need to grow.
Treatment starts with injections, usually followed by a nasal spray.
The nasal spray is typically used six times a day, one spray into each nostril.
Common side-effects include feeling dizzy, tired, or sick.
If symptoms worsen when starting treatment, this usually settles after a couple of weeks.
Tell your doctor if you have other health conditions like diabetes or high blood pressure.
במאמר זה:
Video picks for טיפול בסרטן ותרופות
המשך לקרוא למטה
About buserelin for men
סוג התרופה | A gonadorelin analogue |
שימוש עבור | סרטן הערמונית |
נקרא גם | Suprefact® |
זמין כ | Injection and nasal spray |
Although in many cases סרטן הערמונית is slow-growing, in some men it can be more aggressive and spread to other parts of the body. When this happens, there can be a benefit from using a hormone treatment, such as buserelin, which slows the progress of the cancer.
Prostate cancer cells need the male hormone testosterone to grow. Buserelin works by reducing the production of testosterone and this helps to stop the growth of the cancer cells.
Buserelin is also used in some disorders which affect women. There is a separate medicine leaflet called Buserelin for women which gives more information about this.
Before using buserelin
חזרה לתוכןSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start using buserelin it is important that your doctor knows:
If you have low moods or are depressed.
אם יש לך לחץ דם גבוה (יתר לחץ דם).
If you have diabetes (diabetes mellitus).
If you have a bone disease such as osteoporosis.
אם אתה נוטל או משתמש בתרופות אחרות כלשהן. זה כולל כל תרופה שאתה נוטל שניתן לרכוש ללא מרשם, כמו גם תרופות צמחיות ומשלימות.
אם אי פעם הייתה לך תגובה אלרגית לתרופה.
המשך לקרוא למטה
How to use buserelin
חזרה לתוכןBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about buserelin and will provide you with a full list of the side-effects which you could experience.
When you start buserelin, you will be given injections every eight hours for the first seven days. For convenience, these injections are likely to be given to you while you are in hospital. On the next day, you will be given a nasal spray to use. You must follow the instructions given to you by your doctor for using the spray, but it is usually recommended that you use one spray into each nostril six times each day as follows:
1st dose before your breakfast.
2nd dose after your breakfast.
3rd dose before your midday meal.
4th dose after your midday meal.
5th dose before your evening meal.
6th dose after your evening meal.
Each time you open a new bottle, you will need to attach the nebuliser to the bottle of solution and then 'prime' the spray. You do this by pumping the spray about six or seven times until you see a fine spray produced. Priming fills the nebuliser and tests that the spray is working correctly.
It is important that you use this medicine regularly and space the doses out evenly through the day. If you forget to take a dose at your usual time, take it as soon as you remember. If it is almost time for your next dose then skip the forgotten dose and take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.
About 1 in 10 men notice that their symptoms (usually pain) become worse for a short while when they first start treatment with buserelin. Your doctor is likely to give you some tablets to take during the first few weeks to help prevent this. If you do experience any increase in pain, this will settle again after a couple of weeks.
Please keep your appointments with your doctor so that your progress can be monitored. Your doctor will want you to have regular blood tests to check your hormone levels.
Even if you get a cold or your nose feels blocked, you should continue to use the spray as it will still work. If you are using any other nasal sprays (such as decongestants), you should use buserelin spray first, then wait at least 30 minutes after using buserelin before using the other nasal spray.
Buserelin can affect your blood sugar levels. If you have diabetes you may need to check your blood glucose more frequently. Your doctor will advise you about this.
Can buserelin cause problems?
חזרה לתוכןAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with buserelin. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common buserelin side-effects (these affect fewer than 1 in 10 men) | מה אני יכול לעשות אם אני חווה את זה? |
Feeling dizzy, tired, or sleepy | If this happens, do not drive and do not use tools or machines while affected |
Feeling sick (nausea) or being sick (vomiting), stomach or tummy (abdominal) pain | היצמד למאכלים פשוטים - הימנע ממאכלים עשירים או חריפים |
שלשול | שתו הרבה מים כדי להחליף נוזלים שאבדו |
עצירות | Eat a well-balanced diet and drink several glasses of water each day |
Headache, muscle pain and stiffness | Ask your pharmacist to recommend a suitable painkiller |
Irritation of your nose or throat, nosebleeds, changes in the way things smell and taste, changes in your weight, feeling nervous or depressed, disturbed sleep, being aware of a fast heartbeat, dry skin, acne, changes in the thickness of your hair | אם אחד מאלה הופך לבעייתי, פנה לרופא שלך |
חשוב: In rare cases this medicine may cause a serious allergic reaction. Seek urgent medical attention if you develop a red, itchy skin rash and any difficulties with your breathing, including swelling of the face, lips or tongue. Taking an antihistamine may help slow the reaction whilst you are waiting for treatment.
If you experience any other symptoms which you think may be due to buserelin, please speak with your doctor or pharmacist for further advice.
המשך לקרוא למטה
How to store buserelin
חזרה לתוכןשמור את כל התרופות מחוץ להישג ידם וראייתם של ילדים.
יש לאחסן במקום קריר ויבש, הרחק מחום ואור ישיר.
Each bottle of nasal spray contains one week of treatment. Even if there is some solution left after using the spray for a week, please do not use it. Instead, open a fresh bottle.
מידע חשוב על כל התרופות
חזרה לתוכןמידע חשוב על כל התרופות
אם אתה קונה תרופות כלשהן, בדוק עם רוקח שהן בטוחות לשימוש עם התרופות האחרות שלך.
לעולם אל תיקח יותר מהמינון שנקבע. אם אתה חושד שאתה או מישהו אחר אולי לקח מנת יתר של תרופה זו, פנה למחלקת תאונות וחירום בבית החולים המקומי שלך. קח את המיכל איתך, אפילו אם הוא ריק.
אם אתה עובר ניתוח או טיפול שיניים, אמור לאדם שמבצע את הטיפול אילו תרופות אתה נוטל.
תרופה זו מיועדת עבורך. לעולם אל תיתן אותה לאנשים אחרים, גם אם מצבם נראה דומה לשלך.
אל תשמרו תרופות שפג תוקפן או שאינן רצויות. קחו אותן לבית המרקחת המקומי שלכם שיטפל בהן עבורכם.
אם יש לך שאלות לגבי התרופה הזו, שאל את הרוקח שלך.
דווח על תופעות לוואי לתרופה או חיסון
אם אתה חווה תופעות לוואי, תוכל לדווח עליהן באינטרנט דרך ה Yellow Card website.

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שאלות נפוצות
Why is buserelin recommended for my prostate cancer?
Buserelin is used for prostate cancer because cancer cells need the male hormone testosterone to grow. Buserelin works by reducing the production of testosterone, which helps to stop the growth of the cancer cells.
I've heard prostate cancer can be slow-growing. Is buserelin still necessary?
While prostate cancer can indeed be slow-growing in many cases, in some men it can be more aggressive and spread to other parts of the body. When this occurs, hormone treatments like buserelin can be beneficial in slowing the cancer's progress.
What should I do if my symptoms, like pain, get worse when I first start buserelin?
About 1 in 10 men notice a temporary worsening of symptoms, usually pain, when they first start buserelin treatment. Your doctor will likely give you tablets to help prevent this during the first few weeks. If you do experience increased pain, it should settle down after a couple of weeks.
Can I use other nasal sprays while using buserelin?
Yes, you can use other nasal sprays, such as decongestants. However, you should always use the buserelin spray first, and then wait at least 30 minutes before using any other nasal spray.
What if I miss a dose of my buserelin nasal spray?
If you forget to take a dose at your usual time, take it as soon as you remember. If it is almost time for your next dose, then skip the forgotten dose and take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.
How often will I need to see my doctor while on buserelin?
You will have regular appointments with your doctor so that your progress can be monitored. Your doctor will also arrange for regular blood tests to check your hormone levels.
I have diabetes. Will buserelin affect my blood sugar?
Buserelin can affect your blood sugar levels. If you have diabetes, you may need to check your blood glucose more frequently. Your doctor will provide guidance on this.
How should I store my buserelin nasal spray?
Keep all medicines out of the reach and sight of children. Store your buserelin in a cool, dry place, away from direct heat and light. Each bottle of nasal spray contains one week of treatment; even if there is solution left after a week, you should open a fresh bottle.
קריאה נוספת והפניות
- Manufacturer’s PIL, Suprefact® 100 micrograms Nasal Spray Solution; Neon Healthcare Ltd, The electronic Medicines Compendium. Dated October 2020.
- תרופות מלאות BNF מהדורה 89; האגודה הרפואית הבריטית והחברה המלכותית לפרמקולוגיה של בריטניה הגדולה, לונדון.
המשך לקרוא למטה
About the authorView full bio

מייקל סטיוארט, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

סיד דג'אני
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
היסטוריית המאמר
המידע בעמוד זה נכתב ונבדק על ידי קלינאים מוסמכים.
Next review due: 3 Sept 2027
14 Sept 2024 | הגרסה האחרונה

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