Primidone for epilepsy
Enodama
נבדק על ידי Sid Dajaniעודכן לאחרונה על ידי Michael Stewart, MRPharmSLast updated 5 אפריל 2025
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You need to take primidone regularly to prevent seizures from occurring. It is usually taken twice daily.
It may cause you to feel drowsy.
Do not drink alcohol.
Do not suddenly stop taking it as this is likely to make your fits return.
At a glance
Primidone is an anti-epileptic medicine used to prevent seizures.
It is available as tablets and an oral liquid medicine.
Take primidone exactly as your doctor tells you, usually twice a day.
Do not stop taking this medicine suddenly, as this can cause seizures to return.
If you forget a dose, take it as soon as you remember, unless it is nearly time for your next dose.
Be aware of side effects like feeling sick or tired, and tell your doctor if they persist.
Seek medical help immediately if you experience a high temperature, severe rash, or yellow skin or eyes.
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About primidone
סוג התרופה | Anti-epileptic |
שימוש עבור | אפילפסיה |
נקרא גם | Enodama®, Liskantin®, Mysoline® |
זמין כ | Tablets, oral liquid medicine |
If you have אפילפסיה, it means that you have had repeated fits (seizures). A seizure is a short episode of symptoms caused by a burst of abnormal electrical activity in your brain. Different parts of the brain control different parts and functions of your body. Therefore, the symptoms that occur during a seizure depend on where the abnormal burst of electrical activity occurs. Symptoms that may occur during a seizure can affect your muscles, sensations, behaviour, emotions, consciousness, or a combination of these.
Epilepsy cannot be 'cured', but the seizures can be prevented in most people by suitable anti-epileptic medication. Primidone helps prevent seizures from occurring.
Before taking primidone
חזרה לתוכןSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking primidone it is important that your doctor or pharmacist knows:
אם את בהריון, מנסה להיכנס להריון או מניקה.
If you have breathing problems.
If you have ever had problems with drug or alcohol dependence.
אם יש לך בעיות בכבד או בכליות.
If you have a rare inherited blood disorder known as porphyria.
If you are taking or using any other medicines. This includes any medicines which are available to buy without a prescription, as well as herbal and complementary medicines.
אם אי פעם הייתה לך תגובה אלרגית לתרופה.
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How to take primidone
חזרה לתוכןBefore you start this treatment, read the manufacturer's printed information leaflet from inside the pack. The leaflet will give you more information about primidone and a full list of side-effects which you may experience from taking it.
Take primidone exactly as your doctor has told you. It is usually taken twice a day, although to begin with you will be prescribed a small dose to take at bedtime. This will then be increased gradually. Increasing your dose slowly allows your doctor to make sure that you have the dose that best suits you, but avoids any unwanted symptoms. Your dose will be on the label of your pack to remind you how to take the tablets. You need to take primidone regularly to prevent the fits (seizures) from occurring.
You can take the tablets before or after food. You may find it helps to swallow them with a drink of water.
If you forget to take a dose, take it as soon as you remember. If it is almost time to take your next dose, skip the missed dose and take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.
להפיק את המרב מהטיפול שלך
חזרה לתוכןנסה לשמור על הפגישות הקבועות שלך עם הרופא. זה כדי שהרופא יוכל לבדוק את ההתקדמות שלך.
When you first start a new treatment for epilepsy there may be a change in the number or type of fits (seizures) you experience. Your doctor will advise you about this.
Different brands of primidone may act in a slightly different way in your body. Because of this your pharmacist will always try to give you tablets from the same manufacturer as you have had before. So, each time you collect a prescription, check to make sure your supply looks the same and that the brand name is the same. If you are unsure, or if you have any questions about your prescription, please ask your pharmacist to check it for you.
People with epilepsy must stop driving at first. Your doctor will advise you about when it may be possible for you to resume driving again. This will usually be after a year free of seizures.
Do not stop taking this medicine unless your doctor tells you to do so. Stopping it suddenly can cause your seizures to return and your doctor will want you to reduce your dose gradually if this is necessary. Also, taking primidone over a time may lead to your body becoming dependent on it and this is another reason why your doctor will want to reduce your dose slowly.
Emotional stress or a lack of sleep could make you more likely to have a seizure. Keeping to a regular sleep pattern and using relaxation exercises can reduce this risk. Speak with your doctor or pharmacist for advice.
If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking primidone.
If you buy any medicines, check with a pharmacist that they are suitable for you to take alongside primidone.
If you are a woman using hormonal contraception ('the pill'), discuss this with your doctor as primidone interferes with the pill, reducing its contraceptive effect. Other methods of contraception will be more suitable for you. If you want to have a family, make sure you discuss this with your doctor well in advance of becoming pregnant. This is so that you can be given advice from a specialist before you become pregnant. If you become pregnant while you are taking primidone, you should tell your doctor straightaway.
You are advised not to drink alcohol while you are on primidone. Primidone will make you feel sleepy and drinking alcohol will increase this.
While you are taking these tablets, there is a small risk that you may develop mood changes or distressing feelings, and thoughts about suicide. If this happens, you must tell your doctor straightaway.
המשך לקרוא למטה
Can primidone cause problems?
חזרה לתוכןלצד ההשפעות המועילות שלהן, רוב התרופות יכולות לגרום לתופעות לוואי לא רצויות, אם כי לא כולם חווים אותן. תופעות אלו בדרך כלל משתפרות כאשר הגוף שלך מתרגל לתרופה החדשה, אך יש לפנות לרופא או לרוקח אם אחת מתופעות הלוואי הבאות נמשכת או הופכת למטרידה.
Common primidone side-effects | מה אני יכול לעשות אם אני חווה את זה? |
Feeling unsteady or tired | Getting up or moving more slowly should help. If this continues, let your doctor know |
Feeling sleepy, eyesight problems | Make sure your reactions are normal before you use tools or machines |
תחושת בחילה (נוזאה) | היצמד למאכלים פשוטים - הימנע ממאכלים עשירים או חריפים |
Feeling short of breath, behavioural changes, mood changes (such as feeling irritable, confused, excited or depressed) | אם אחד מאלה הופך לבעייתי, פנה לרופא שלך |
חשוב: your doctor will have discussed with you the possibility of some less common but more serious side-effects. Let your doctor know straightaway if you experience any of the following:
A high temperature (fever) and swollen glands.
A severe skin rash.
Yellowing of your skin or the whites of your eyes (jaundice).
אם אתה חווה תסמינים נוספים שלדעתך עשויים להיות כתוצאה מתרופה זו, פנה לרופא או לרוקח שלך.
How to store primidone
חזרה לתוכןשמור את כל התרופות מחוץ להישג ידם וראייתם של ילדים.
יש לאחסן במקום קריר ויבש, הרחק מחום ואור ישיר.
מידע חשוב על כל התרופות
חזרה לתוכןמידע חשוב על כל התרופות
לעולם אל תיקח יותר מהמינון שנקבע. אם אתה חושד שאתה או מישהו אחר אולי לקח מנת יתר של תרופה זו, פנה מיד לחדר המיון בבית החולים המקומי שלך. קח איתך את המיכל, אפילו אם הוא ריק.
תרופה זו מיועדת עבורך. לעולם אל תיתן אותה לאנשים אחרים, גם אם מצבם נראה דומה לשלך.
אל תשמרו תרופות שפג תוקפן או שאינן רצויות. קחו אותן לבית המרקחת המקומי שלכם שיטפל בהן עבורכם.
אם יש לך שאלות לגבי התרופה הזו, שאל את הרוקח שלך.
דווח על תופעות לוואי לתרופה או חיסון
אם אתה חווה תופעות לוואי, תוכל לדווח עליהן באינטרנט דרך ה Yellow Card website.

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שאלות נפוצות
What should I do if I accidentally miss a dose of primidone?
If you forget to take a dose, take it as soon as you remember. However, if it's almost time for your next scheduled dose, you should skip the one you missed and just take your next dose as planned. It's important not to take two doses together to compensate for a forgotten one.
Are there any specific foods or drinks I should avoid while taking primidone?
You can take primidone tablets before or after food. However, you are advised not to drink alcohol while on primidone, as it can increase the sleepy feeling that primidone might cause. If you experience feeling sick (nausea), sticking to simple foods and avoiding rich or spicy meals may help.
How long will I need to take primidone for?
Primidone helps prevent seizures from occurring, but epilepsy cannot be 'cured'. You should not stop taking this medicine unless your doctor tells you to do so, as stopping it suddenly can cause your seizures to return. Your doctor will want you to reduce your dose gradually if it is necessary to stop.
Can I drive if I am taking primidone for epilepsy?
People with epilepsy must stop driving at first. Your doctor will advise you about when it may be possible for you to resume driving, which is usually after a year of being free of seizures. Primidone can also cause side-effects like feeling sleepy or having eyesight problems, so you must make sure your reactions are normal before using tools or machines, including driving.
What should I do if I experience mood changes or distressing thoughts while on primidone?
While taking primidone, there is a small risk that you may develop mood changes or distressing feelings, including thoughts about suicide. If this happens, you must tell your doctor straightaway.
What should I do with primidone that is no longer needed or has expired?
You should not keep out-of-date or unwanted medicines. Take them to your local pharmacy, which will dispose of them for you safely.
קריאה נוספת והפניות
- Manufacturer's PIL, Primidone 250 mg Tablets; SERB Laboratories, The electronic Medicines Compendium. Dated February 2024.
- תרופות מלאות BNF מהדורה 89; האגודה הרפואית הבריטית והחברה המלכותית לפרמקולוגיה של בריטניה הגדולה, לונדון.
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About the authorView full bio

מייקל סטיוארט, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

סיד דג'אני
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
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הסקירה הבאה מתוכננת ל: 5 אפריל 2028
5 אפריל 2025 | הגרסה האחרונה

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