פירזינאמיד לשחפת

Zinamide

נבדק על ידי Sid Dajaniעודכן לאחרונה על ידי מייקל סטיוארט, MRPharmSעודכן לאחרונה 19 יול 2023

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Pyrazinamide is one of several medicines that you will need to take to treat tuberculosis (TB).

It is important that you take the tablets regularly.

Pyrazinamide can sometimes cause liver problems. Let your doctor know straightaway if you develop sickness, a high temperature (fever), tenderness in your tummy (abdomen), or yellowing of your skin or the whites of your eyes (jaundice).

About pyrazinamide

סוג התרופה	An antituberculosis medicine
שימוש עבור	שחפת (TB)
נקרא גם	Zinamide® Combination brands: Rifater® (איזוניאזיד עם rifampicin and pyrazinamide); Voractiv®, Rimstar® (isoniazid with rifampicin, pyrazinamide and אתמבוטול)
זמין כ	טבליות

Pyrazinamide is used to treat שחפת (TB). TB is a bacterial infection which mostly affects the lungs, but which can affect any part of your body. It is treatable with a course of medicines which usually lasts for six months in total. You will need to take several medicines to treat TB - pyrazinamide is just one of the medicines prescribed. You will be prescribed pyrazinamide to take during the first two months of your treatment.

Pyrazinamide is usually prescribed as a tablet which contains a combination of three or four medicines to treat TB. The brand names of these are Rifater®, Rimstar® and Voractiv®. Taking a combination brand helps to reduce the total number of tablets you need to take each day. You may be prescribed one of these combination brands, or alternatively you may be prescribed a tablet containing only pyrazinamide (brand name Zinamide®). This brand must be taken alongside other medicines for TB.

Before taking pyrazinamide

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking pyrazinamide it is important that your doctor knows:

אם את בהריון או מניקה.
If you have any problems with the way your kidneys work, or the way your liver works.
If you have gout or diabetes.
If you drink a lot of alcohol.
אם יש לך פורפיריה, הפרעת דם תורשתית נדירה.
אם אתה נוטל תרופות אחרות כלשהן. זה כולל כל תרופה שאתה נוטל שניתן לרכוש ללא מרשם, כמו גם תרופות צמחיות ומשלימות.
אם אי פעם הייתה לך תגובה אלרגית לתרופה.

How to take pyrazinamide tablets

Before you start treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about the brand of tablets you have been given and will provide you with a full list of the side-effects which you may experience.
It is important that you take the medicines to treat TB exactly as your doctor tells you to. You will normally be asked to take pyrazinamide every day. Your doctor will explain to you how many tablets to take each day, and this information will be printed on the label of the pack of tablets to remind you. If when you collect your supply of tablets you are unclear about how to take them, ask your pharmacist to explain. If you are undergoing directly observed therapy (DOT), you will be asked to take pyrazinamide three times a week while you are being supervised by a healthcare observer.
It is usually recommended that you take pyrazinamide at the same time of day as your other antituberculosis medicines.

להפיק את המרב מהטיפול שלך

It is important that you keep your regular appointments with your doctor. This is so your doctor can check on your progress. Your doctor may want you to have blood tests from time to time during treatment to make sure that your liver stays healthy.
Continue to take the tablets regularly unless your doctor tells you to stop. This is because it is important for you to complete the treatment course so that the infection does not come back. If for any reason you stop taking the tablets (such as if you think you may be developing side-effects - see also below) then you must let your doctor know about it מייד.
Pyrazinamide may stop the oral typhoid vaccine from working. If you are having any vaccinations, make sure the person treating you knows that you are taking this medicine.
אם אתה עובר ניתוח או טיפול שיניים כלשהו, אמור לאדם שמבצע את הטיפול אילו תרופות אתה נוטל.
If you buy any medicines, check with a pharmacist that they are suitable for you to take with your other medicines.

Can pyrazinamide cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains the most common ones associated with pyrazinamide - please contact your doctor straightaway if you experience these symptoms. You will find a list of other side-effects associated with pyrazinamide in the manufacturer's information leaflet supplied with your medicine.

Common pyrazinamide side-effects

מה אני יכול לעשות אם אני חווה את זה?

Feeling sick (nausea) or being sick (vomiting), lack of appetite, high temperature (fever), feeling generally unwell, tender abdomen, yellowing of your skin or of the whites of your eyes (jaundice)

Stop taking pyrazinamide and contact your doctor

מייד

. These are signs of a problem with your liver and your doctor will want it investigating as soon as possible

אם אתה חווה תסמינים נוספים שלדעתך עשויים להיות כתוצאה מהתרופה, פנה לרופא או לרוקח שלך לקבלת ייעוץ נוסף.

How to store pyrazinamide

שמור את כל התרופות מחוץ להישג ידם וראייתם של ילדים.
יש לאחסן במקום קריר ויבש, הרחק מחום ואור ישיר.

מידע חשוב על כל התרופות

לעולם אל תיקח יותר מהמינון שנקבע. אם אתה חושד שאתה או מישהו אחר אולי לקח מנת יתר של תרופה זו, פנה למחלקת תאונות וחירום בבית החולים המקומי שלך. קח את המיכל איתך, אפילו אם הוא ריק.

תרופה זו מיועדת עבורך. לעולם אל תיתן אותה לאנשים אחרים, גם אם מצבם נראה דומה לשלך.

אל תשמרו תרופות שפג תוקפן או שאינן רצויות. קחו אותן לבית המרקחת המקומי שלכם שיטפל בהן עבורכם.

אם יש לך שאלות לגבי התרופה הזו, שאל את הרוקח שלך.

דווח על תופעות לוואי לתרופה או חיסון

אם אתה חווה תופעות לוואי, תוכל לדווח עליהן באינטרנט דרך ה אתר כרטיס צהוב.

שאלות נפוצות

Why do I need to take pyrazinamide for only the first two months of my TB treatment?

Pyrazinamide is part of a multi-drug regimen for tuberculosis. It is typically prescribed for the initial two months of treatment because its role is most critical during this phase to effectively combat the infection.

Can I take over-the-counter medicines or herbal remedies while taking pyrazinamide?

If you are taking any other medicines, including those available without a prescription, as well as herbal or complementary medicines, it's important to inform your doctor. You should also check with a pharmacist to ensure they are suitable to take with pyrazinamide and your other medications.

What is 'directly observed therapy' (DOT) and how does it affect how I take pyrazinamide?

Directly observed therapy (DOT) is a way of taking your medication where a healthcare observer supervises you. If you are undergoing DOT, you will typically be asked to take pyrazinamide three times a week under this supervision, rather than every day.

What should I do if I forget to take my pyrazinamide dose?

The article stresses the importance of taking your tablets regularly and exactly as your doctor tells you. If you miss a dose, or are unclear about what to do, you should ask your pharmacist to explain, or contact your doctor's office.

השאלות והתשובות הללו נוצרו מהמידע במאמר זה.