Cobicistat tablets for HIV

About cobicistat

Cobicistat is prescribed for human immunodeficiency virus (HIV) infection. HIV destroys cells in the body, called CD4 T cells. These cells are a type of white blood cell and are important because they are involved in protecting your body from infection. If left untreated, the HIV infection weakens your immune system so that your body cannot defend itself against bacteria, viruses and other germs. You will be prescribed three or more antiretroviral medicines at the same time, as taking a combination of different medicines is more effective than taking one alone, and also it reduces the risk that the HIV virus will become resistant to any individual medicine. Antiretroviral medicines slow the progress of HIV infection, but do not cure it.

Cobicistat will be prescribed for you by a doctor who is a specialist. You will also have been prescribed either atazanavir or darunavir for the HIV infection. Cobicistat is given to boost the effect of these medicines. Atazanavir and darunavir are both protease inhibitor antiretroviral medicines. Cobicistat helps to improve the effectiveness of these medicines by slowing down their breakdown in the body. This increases the amount of time atazanavir or darunavir is present in your body.

Some brands of cobicistat contain other antiretroviral medicines also (see the list in the table above). Taking one of these brands helps to reduce the number of tablets you need to take each day. Not all of the information in this leaflet applies to the combination brands - please refer to the manufacturer's printed information leaflet from inside the pack for full details about these brands. You will also find more information about each of the individual medicines on our website (see atazanavir, darunavir, emtricitabine, tenofovir).

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking cobicistat it is important that your doctor knows:

• אם את בהריון, מנסה להיכנס להריון, או מניקה.

• If you have any problems with the way your liver works, or if you have problems with the way your kidneys work.

• אם אי פעם הייתה לך תגובה אלרגית לתרופה.

• אם אתה נוטל תרופות אחרות כלשהן. זה כולל כל תרופה שניתן לרכוש ללא מרשם, כמו גם תרופות צמחיות ומשלימות.

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about cobicistat, and it will also provide you with a full list of the side-effects which you could experience from taking it.

• Take cobicistat exactly as your doctor tells you to. Take one tablet a day, at the same time as either atazanavir or darunavir.

• Swallow the tablet whole with a drink of water. Take the tablet after a meal or a snack.

• If you forget to take a dose, take it as soon as you remember, providing it is within 12 hours of the time you should have taken it. Remember to take the tablet with something to eat. However, if when you remember, it is more than 12 hours late, do not take the dose you missed but instead take your next dose when it is due. Do נחשבת take two doses together to make up for the forgotten dose.

• Keep your regular appointments with your doctor so that your progress can be monitored. You are likely to need regular blood tests to check how well your medicines are working.

• It is important that you continue to take your antiretroviral treatment regularly. This will help to prevent the HIV from becoming resistant to the medicines you are taking. Even if you miss only a small number of doses, the virus can become resistant to treatment.

• If you develop an infection soon after you start the treatment, let your doctor know. As a result of taking antiretroviral medicines, your immune system may start fighting an infection which was present before you started the treatment, but which you may not have been aware of.

• Although treatment with antiretroviral medicines may reduce the risk of you passing HIV to others through sexual contact, it does not stop it. It is important that you use condoms.

• If you are trying for a baby or you become pregnant whilst taking cobicistat, let your doctor know straightaway. Your doctor may recommend a different treatment combination that could be more effective during pregnancy.

• It is not uncommon for people with HIV to feel low or even depressed, especially soon after the diagnosis has been made and treatment has been started. If you have any feelings of depression, or any distressing thoughts about harming yourself then you should speak with your doctor straightaway.

• If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking cobicistat and antiretroviral medicines.

• If you buy any medicines, supplements or herbal remedies 'over the counter', check with a pharmacist that they are suitable to take with cobicistat and your other medicines. This is because cobicistat can interfere with some medicines and stop them from working properly.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with cobicistat. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

אם אתה חווה תסמינים נוספים שלדעתך עשויים להיות כתוצאה מהתרופה, פנה לרופא או לרוקח שלך לקבלת ייעוץ נוסף.

• שמור את כל התרופות מחוץ להישג ידם וראייתם של ילדים.

• Store the tablets in the original container in a cool, dry place, away from direct heat and light.