Cycloserine for tuberculosis

About cycloserine

Cycloserine is used to treat שחפת (TB). TB is a bacterial infection which mostly affects the lungs, but which can affect any part of your body. TB is treatable with a course of medicines which usually lasts for six months. You will need to take several medicines to treat TB - cycloserine is one of the medicines used. Cycloserine will be prescribed for you if other more frequently prescribed antituberculosis medicines are either not suitable for you, or have not been effective for you.

Cycloserine works by acting on the cell walls of the germs (bacteria) responsible for the TB. The cell walls do not form correctly which causes them to break, killing the bacteria.

Cycloserine will be prescribed for you by a doctor who specialises in the treatment of TB. It is important that you take it regularly.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking cycloserine it is important that your doctor knows:

• אם את בהריון או מניקה.

• If you drink a lot of alcohol.

• If you have any mental health problems, such as anxiety, depression or psychosis.

• If you have any problems with how your liver works, or any problems with the way your kidneys work.

• If you have a condition that causes fits, such as epilepsy.

• אם יש לך הפרעת דם תורשתית נדירה הנקראת פורפיריה.

• אם אתה נוטל תרופות אחרות כלשהן. זה כולל כל תרופה שניתן לרכוש ללא מרשם, כמו גם תרופות צמחיות ומשלימות.

• אם אי פעם הייתה לך תגובה אלרגית לתרופה.

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about cycloserine and will provide you with a full list of the side-effects which you could experience from taking it.

• Take the capsules exactly as your doctor tells you to. As a guide, the usual dose to begin with in adults is one capsule twice a day, taken 12 hours apart (morning and evening). After two weeks, your dose may be increased to two capsules twice a day, depending on the result of a blood test.

• Try to take your doses of cycloserine at the same times of day each day, as this will help you to remember to take your doses regularly. You can take the capsules either with or without food.

• If you forget to take a dose, take it as soon as you remember. Try to take the correct number of doses each day, but do not take two doses at the same time to make up for a missed dose.

• It is important that you keep your regular appointments with your doctor, or clinic. This is so your doctor can check on your progress. Your doctor will want you to have blood tests during the treatment, to make sure you have just the right amount of the medicine in your bloodstream. For some people, these tests can be as regular as once a week.

• Continue to take the capsules regularly - do not stop taking cycloserine unless your doctor tells you to stop. This is because it is important for you to complete the course of medicine so that the infection does not come back. Your treatment will last for several months.

• Do not to drink alcohol while you are on cycloserine. Cycloserine causes drowsiness, and drinking alcohol will increase the chance that you experience this side-effect. It also increases the risk of more serious side-effects, such as fits (convulsions).

• Cycloserine can stop the oral typhoid vaccine from working properly. If you are due to have any vaccinations, make sure that the person treating you knows you are taking this medicine. Also, if you are due to have an operation or any dental treatment, you should tell the person carrying out the treatment that you are taking cycloserine for TB.

• If you buy any medicines 'over the counter', check with a pharmacist that they are suitable for you to take alongside your prescribed medicines.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the ones associated with cycloserine. You will find a full list in the manufacturer's information leaflet supplied with the medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

If you experience any other symptoms which you think may be due to the capsules, please speak with your doctor or pharmacist for further advice.

• שמור את כל התרופות מחוץ להישג ידם וראייתם של ילדים.

• יש לאחסן במקום קריר ויבש, הרחק מחום ואור ישיר.