Nabumetone for pain and inflammation

About nabumetone

Anti-inflammatory painkillers like nabumetone are also called non-steroidal anti-inflammatory drugs (NSAIDs), or sometimes just 'anti-inflammatories'. Nabumetone is prescribed for people with אוסטיאוארתריטיס או דלקת מפרקים שגרונית. It eases pain and reduces inflammation.

Nabumetone works by blocking the effect of natural substances called cyclo-oxygenase (COX) enzymes. These enzymes help to make other chemicals in the body, called prostaglandins. Some prostaglandins are produced at sites of injury or damage, and cause pain and inflammation. By blocking the effect of COX enzymes, fewer prostaglandins are produced, which means pain and inflammation are eased.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking nabumetone it is important that your doctor knows:

• אם אי פעם היה לך כיב קיבה או כיב בתריסריון, או אם יש לך מחלת מעי דלקתית כמו מחלת קרוהן או קוליטיס כיבית.

• אם יש לך אסתמה או כל הפרעה אלרגית אחרת.

• אם את בהריון, מנסה להיכנס להריון, או מניקה.

• אם יש לך בעיות בתפקוד הכבד שלך, או אם יש לך בעיות בתפקוד הכליות שלך.

• אם יש לך מצב לב או בעיה בכלי הדם או במחזור הדם.

• אם יש לך לחץ דם גבוה.

• אם יש לך בעיות בקרישת דם.

• אם יש לך הפרעה ברקמת חיבור כמו זאבת מערכתית. זהו מצב דלקתי הנקרא גם זאבת או SLE.

• אם אתה נוטל תרופות אחרות כלשהן. זה כולל כל תרופה שאתה נוטל שניתן לרכוש ללא מרשם, כמו גם תרופות צמחיות ומשלימות.

• If you have ever had an allergic reaction to any other NSAID (such as aspirin, naproxen, ibuprofen, and indometacin), or to any other medicine.

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about nabumetone, and it will also provide you with a full list of the side-effects which you could experience from taking it.

• The usual dose is one or two 500 mg tablets taken daily. You will be asked to take the tablets at the end of the day. If your doctor prescribes a higher dose than this for you, you will be asked to take a dose in the morning as well. This will be in addition to the dose you take in the evening. Take nabumetone exactly as your doctor tells you to.

• You should take nabumetone after a meal, or with a snack. Taking the tablets with some food will help to protect your stomach from side-effects such as indigestion and stomach irritation.

• If you forget to take a dose, don't worry, just take the next dose when it is due. Do not take two doses together to make up for a missed dose.

• Your doctor will try to prescribe you the lowest dose for the shortest time in order to reduce the risk of side-effects. If you need to take nabumetone over a period of time, your doctor may want to prescribe another medicine along with it to protect your stomach from irritation.

• Try to keep any regular appointments with your doctor. This is so your doctor can check on your progress.

• If you have asthma, symptoms such as wheeze or breathlessness can be made worse by anti-inflammatories such as nabumetone. If this happens to you, you should stop taking nabumetone and see a doctor as soon as possible.

• There is known to be a small increased risk of heart and blood vessel problems in people taking some anti-inflammatory painkillers long-term. Your doctor will explain this to you and will prescribe the lowest suitable dose for the shortest time in order to reduce the risk. Do not take more than the recommended dose.

• If you buy any medicines, check with a pharmacist that they are suitable for you to take. This is because you should not take nabumetone with any other anti-inflammatory painkiller, some of which are available in cold and flu remedies which can be bought 'over the counter'.

• If you are due to have an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with nabumetone. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome.

חשוב: if you experience any of the following less common but possibly serious symptoms, stop taking nabumetone and contact a doctor for advice straightaway:

• אם יש לך קשיי נשימה כמו צפצופים או קוצר נשימה.

• אם יש לך סימנים כלשהם לתגובה אלרגית כמו נפיחות סביב הפה או הפנים, או פריחה עורית מגרדת חמורה.

• If you pass blood or black stools, bring up blood, or have severe stomach pains.

אם אתה חווה תסמינים נוספים שלדעתך עשויים להיות כתוצאה מהטבליות, פנה לרופא או לרוקח שלך לקבלת ייעוץ נוסף.

• שמור את כל התרופות מחוץ להישג ידם וראייתם של ילדים.

• יש לאחסן במקום קריר ויבש, הרחק מחום ואור ישיר.